Characteristics of Malignant Pleural Effusion Resident CD8


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
27 Aug 2020
Historique:
received: 20 07 2020
revised: 19 08 2020
accepted: 25 08 2020
entrez: 2 9 2020
pubmed: 2 9 2020
medline: 23 2 2021
Statut: epublish

Résumé

While T cell-based cancer immunotherapies have shown great promise, there remains a need to understand how individual metastatic tumor environments impart local T cell dysfunction. At advanced stages, cancers that metastasize to the pleural space can result in a malignant pleural effusion (MPE) that harbors abundant tumor and immune cells, often exceeding 10

Identifiants

pubmed: 32867034
pii: ijms21176178
doi: 10.3390/ijms21176178
pmc: PMC7503595
pii:
doi:

Substances chimiques

CCR7 protein, human 0
IFNG protein, human 0
IL7R protein, human 0
Interleukin-7 Receptor alpha Subunit 0
Receptors, CCR7 0
Lactic Acid 33X04XA5AT
Interferon-gamma 82115-62-6
L-Lactate Dehydrogenase EC 1.1.1.27
Leukocyte Common Antigens EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R01 CA233521
Pays : United States

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Auteurs

Rajeev Dhupar (R)

Surgical Services Division, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA.
Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Olugbenga T Okusanya (OT)

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Seth H Eisenberg (SH)

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Sara E Monaco (SE)

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Ayana T Ruffin (AT)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Dongyan Liu (D)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

James D Luketich (JD)

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Udai S Kammula (US)

Department of Surgery, Division of Surgical Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Tullia C Bruno (TC)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Michael T Lotze (MT)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Department of Surgery, Division of Surgical Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Department of Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Adam C Soloff (AC)

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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Classifications MeSH