The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
20
02
2020
accepted:
24
08
2020
pubmed:
2
9
2020
medline:
26
1
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
The two closely related RabGTPase-activating proteins (RabGAPs) TBC1D1 and TBC1D4 play a crucial role in the regulation of GLUT4 translocation in response to insulin and contraction in skeletal muscle. In mice, deficiency in one or both RabGAPs leads to reduced insulin- and contraction-stimulated glucose uptake and to elevated fatty acid (FA) uptake and oxidation in both glycolytic and oxidative muscle fibers without altering mitochondrial copy number and the abundance of proteins for oxidative phosphorylation. Here we present evidence for a novel mechanism of skeletal muscle lipid utilization involving the two RabGAPs and the FA transporter SLC27A4/FATP4. Both RabGAPs control the uptake of saturated and unsaturated long-chain FAs (LCFAs) into skeletal muscle and knockdown (Kd) of a subset of RabGAP substrates,
Identifiants
pubmed: 32868338
pii: db20-0180
doi: 10.2337/db20-0180
doi:
Substances chimiques
Fatty Acid Transport Proteins
0
Fatty Acids
0
GTPase-Activating Proteins
0
Slc27a4 protein, mouse
0
Tbc1d1 protein, mouse
0
Tbc1d4 protein, mouse
0
Banques de données
figshare
['10.2337/figshare.12857771']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2281-2293Informations de copyright
© 2020 by the American Diabetes Association.