Alexandra Chadt

Affiliations

Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
German Center for Diabetes Research, München-Neuherberg, Germany.

Publications (28)

RabGAPs in skeletal muscle function and exercise.

Journal of molecular endocrinology

Avec: Lena Espelage , Hadi Al-Hasani , Alexandra Chadt

TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction.

Diabetes

Avec: Rasmus Kjøbsted , Alexandra Chadt , Nicolas O Jørgensen , Kohei Kido , Jeppe K Larsen , Christian de Wendt , Hadi Al-Hasani , Jørgen F P Wojtaszewski

Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1.

Diabetes

Avec: Christian de Wendt , Lena Espelage , Samaneh Eickelschulte , Christian Springer , Laura Toska , Anna Scheel , Awovi Didi Bedou , Tim Benninghoff , Sandra Cames , Torben Stermann , Alexandra Chadt , Hadi Al-Hasani

Identification of Novel Genes Involved in Hyperglycemia in Mice.

International journal of molecular sciences

Avec: Wenke Jonas , Oliver Kluth , Anett Helms , Sarah Voß , Markus Jähnert , Pascal Gottmann , Thilo Speckmann , Birgit Knebel , Alexandra Chadt , Hadi Al-Hasani , Annette Schürmann , Heike Vogel

Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle.

Diabetes

Avec: Jeppe K Larsen , Magnus R Larsen , Jesper B Birk , Dorte E Steenberg , Janne R Hingst , Kurt Højlund , Alexandra Chadt , Hadi Al-Hasani , Atul S Deshmukh , Jørgen F P Wojtaszewski , Rasmus Kjøbsted

A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium.

Journal of cell science

Avec: Angéline Geiser , Susan Currie , Hadi Al-Hasani , Alexandra Chadt , Gail McConnell , Gwyn W Gould

Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise.

Frontiers in endocrinology

Avec: Anna Rita Minafra , Alexandra Chadt , Puyan Rafii , Hadi Al-Hasani , Kristina Behnke , Jürgen Scheller

Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high-fat diet-fed mouse model.

Diabetes, obesity & metabolism

Avec: Kálmán Bódis , Saida Breuer , Assja Crepzia-Pevzner , Oana-Patricia Zaharia , Martin Schön , Nina Saatmann , Delsi Altenhofen , Christian Springer , Julia Szendroedi , Robert Wagner , Hadi Al-Hasani , Michael Roden , Dominik Pesta , Alexandra Chadt , Auteur inconnu

Depletion of TBC1D4 improves the metabolic exercise response by overcoming genetically induced peripheral insulin resistance.

Diabetes

Avec: Christian Springer , Christian Binsch , Deborah Weide , Laura Toska , Anna Lena Cremer , Heiko Backes , Anna K Scheel , Lena Espelage , Jörg Kotzka , Sebastian Sill , Anette Kurowski , Daebin Kim , Sandra Karpinski , Theresia M Schnurr , Torben Hansen , Sonja Hartwig , Stefan Lehr , Sandra Cames , Jens Brüning , Matthias Lienhard , Ralf Herwig , Stefan Börno , Bernd Timmermann , Hadi Al-Hasani , Alexandra Chadt

Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle.

Molecular metabolism

Avec: Oleksiy Klymenko , Tim Brecklinghaus , Matthias Dille , Christian Springer , Christian de Wendt , Delsi Altenhofen , Christian Binsch , Birgit Knebel , Jürgen Scheller , Christopher Hardt , Ralf Herwig , Alexandra Chadt , Paul T Pfluger , Hadi Al-Hasani , Dhiraj G Kabra

Identification of Novel Potential Type 2 Diabetes Genes Mediating β-Cell Loss and Hyperglycemia Using Positional Cloning.

Frontiers in genetics

Avec: Heja Aga , Nicole Hallahan , Pascal Gottmann , Markus Jaehnert , Sophie Osburg , Gunnar Schulze , Anne Kamitz , Danny Arends , Gudrun Brockmann , Tanja Schallschmidt , Sandra Lebek , Alexandra Chadt , Hadi Al-Hasani , Hans-Georg Joost , Annette Schürmann , Heike Vogel

Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers.

Diabetologia

Avec: Theresia M Schnurr , Emil Jørsboe , Alexandra Chadt , Inger K Dahl-Petersen , Jonas M Kristensen , Jørgen F P Wojtaszewski , Christian Springer , Peter Bjerregaard , Søren Brage , Oluf Pedersen , Ida Moltke , Niels Grarup , Hadi Al-Hasani , Anders Albrechtsen , Marit E Jørgensen , Torben Hansen

Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Sarah Görigk , D Margriet Ouwens , Tanja Kuhn , Delsi Altenhofen , Christian Binsch , Mareike Damen , Jenny Minh-An Khuong , Katharina Kaiser , Birgit Knebel , Heike Vogel , Annette Schürmann , Alexandra Chadt , Hadi Al-Hasani

Skeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.

Journal of cachexia, sarcopenia and muscle

Avec: Georgia Lenihan-Geels , Francisco Garcia Carrizo , Marina Leer , Sabrina Gohlke , Moritz Oster , Sophie Pöhle-Kronawitter , Christiane Ott , Alexandra Chadt , Isabel N Reinisch , Markus Galhuber , Chen Li , Wenke Jonas , Markus Jähnert , Susanne Klaus , Hadi Al-Hasani , Tilman Grune , Annette Schürmann , Tobias Madl , Andreas Prokesch , Michael Schupp , Tim J Schulz

Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development.

Mammalian genome : official journal of the International Mammalian Genome Society

Avec: Sayeed Ur Rehman , Tanja Schallschmidt , Axel Rasche , Birgit Knebel , Torben Stermann , Delsi Altenhofen , Ralf Herwig , Annette Schürmann , Alexandra Chadt , Hadi Al-Hasani

AKT/AMPK-mediated phosphorylation of TBC1D4 disrupts the interaction with insulin-regulated aminopeptidase.

The Journal of biological chemistry

Avec: Samaneh Eickelschulte , Sonja Hartwig , Ben Leiser , Stefan Lehr , Viola Joschko , Manopriya Chokkalingam , Alexandra Chadt , Hadi Al-Hasani

AMPK and Beyond: The Signaling Network Controlling RabGAPs and Contraction-Mediated Glucose Uptake in Skeletal Muscle.

International journal of molecular sciences

Avec: Leon Peifer-Weiß , Hadi Al-Hasani , Alexandra Chadt

Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene.

Human molecular genetics

Avec: Tanja Kuhn , Katharina Kaiser , Sandra Lebek , Delsi Altenhofen , Birgit Knebel , Ralf Herwig , Axel Rasche , Angela Pelligra , Sarah Görigk , Jenny Minh-An Khuong , Heike Vogel , Annette Schürmann , Matthias Blüher , Alexandra Chadt , Hadi Al-Hasani

Inhibition of proline-rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes.

British journal of pharmacology

Avec: Ralf Erkens , Dragos Andrei Duse , Amanda Brum , Alexandra Chadt , Stefanie Becher , Mauro Siragusa , Christine Quast , Johanna Müssig , Michael Roden , Miriam Cortese-Krott , Borja Ibáñez , Eckhard Lammert , Ingrid Fleming , Christian Jung , Hadi Al-Hasani , Gerd Heusch , Malte Kelm

The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.

Diabetes

Avec: Tim Benninghoff , Lena Espelage , Samaneh Eickelschulte , Isabel Zeinert , Isabelle Sinowenka , Frank Müller , Christina Schöndeling , Hannah Batchelor , Sandra Cames , Zhou Zhou , Jörg Kotzka , Alexandra Chadt , Hadi Al-Hasani

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease.

Pflugers Archiv : European journal of physiology

Avec: Alexandra Chadt , Hadi Al-Hasani

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.

Journal of hepatology

Avec: Kristin Schwerbel , Anne Kamitz , Natalie Krahmer , Nicole Hallahan , Markus Jähnert , Pascal Gottmann , Sandra Lebek , Tanja Schallschmidt , Danny Arends , Fabian Schumacher , Burkhard Kleuser , Tom Haltenhof , Florian Heyd , Sofiya Gancheva , Karl W Broman , Michael Roden , Hans-Georg Joost , Alexandra Chadt , Hadi Al-Hasani , Heike Vogel , Wenke Jonas , Annette Schürmann

AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction.

Diabetes

Avec: Rasmus Kjøbsted , Julie L W Roll , Nicolas O Jørgensen , Jesper B Birk , Marc Foretz , Benoit Viollet , Alexandra Chadt , Hadi Al-Hasani , Jørgen F P Wojtaszewski

TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes.

Scientific reports

Avec: Sharon C Hook , Alexandra Chadt , Kate J Heesom , Shosei Kishida , Hadi Al-Hasani , Jeremy M Tavaré , Elaine C Thomas

Many Ways to Rome: Exercise, Cold Exposure and Diet-Do They All Affect BAT Activation and WAT Browning in the Same Manner?

International journal of molecular sciences

Avec: Anna K Scheel , Lena Espelage , Alexandra Chadt

Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion.

Cardiovascular diabetology

Avec: C Binsch , D M Barbosa , G Hansen-Dille , M Hubert , S M Hodge , M Kolasa , K Jeruschke , J Weiß , C Springer , S Gorressen , J W Fischer , M Lienhard , R Herwig , S Börno , B Timmermann , A L Cremer , H Backes , A Chadt , H Al-Hasani

E96V Mutation in the

International journal of molecular sciences

Avec: Delsi Altenhofen , Jenny Minh-An Khuong , Tanja Kuhn , Sandra Lebek , Sarah Görigk , Katharina Kaiser , Christian Binsch , Kerstin Griess , Birgit Knebel , Bengt-Frederik Belgardt , Sandra Cames , Samaneh Eickelschulte , Torben Stermann , Axel Rasche , Ralf Herwig , Jürgen Weiss , Heike Vogel , Annette Schürmann , Alexandra Chadt , Hadi Al-Hasani

Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse.

Frontiers in endocrinology

Avec: Inka Rapöhn , Ivet Elias , Juliane Weiner , Anna Pujol , Stephanie Kehr , Alexandra Chadt , Hadi Al-Hasani , Ralph Burkhardt , Nora Klöting , Michael Stumvoll , Fatima Bosch , Peter Kovacs , John T Heiker , Jana Breitfeld

Réseau de co-auteurs

Hadi Al-Hasani 26 collaborations

Annette Schürmann 8 collaborations

Birgit Knebel 6 collaborations

Heike Vogel 6 collaborations

Delsi Altenhofen 6 collaborations

Lena Espelage 5 collaborations

Christian Springer 5 collaborations

Ralf Herwig 5 collaborations

Jørgen F P Wojtaszewski 4 collaborations

Samaneh Eickelschulte 4 collaborations

Sandra Cames 4 collaborations

Christian Binsch 4 collaborations

Sandra Lebek 4 collaborations

Rasmus Kjøbsted 3 collaborations

Christian de Wendt 3 collaborations

Torben Stermann 3 collaborations

Wenke Jonas 3 collaborations

Markus Jähnert 3 collaborations

Pascal Gottmann 3 collaborations

Michael Roden 3 collaborations

Tanja Schallschmidt 3 collaborations

Sarah Görigk 3 collaborations

Tanja Kuhn 3 collaborations

Jenny Minh-An Khuong 3 collaborations

Katharina Kaiser 3 collaborations

Axel Rasche 3 collaborations

Nicolas O Jørgensen 2 collaborations

Jeppe K Larsen 2 collaborations

Laura Toska 2 collaborations

Tim Benninghoff 2 collaborations

Jesper B Birk 2 collaborations

Jürgen Scheller 2 collaborations

Anna K Scheel 2 collaborations

Jörg Kotzka 2 collaborations

Theresia M Schnurr 2 collaborations

Torben Hansen 2 collaborations

Sonja Hartwig 2 collaborations

Stefan Lehr 2 collaborations

Nicole Hallahan 2 collaborations

Anne Kamitz 2 collaborations

Danny Arends 2 collaborations

Hans-Georg Joost 2 collaborations

Kohei Kido 1 collaboration

Anna Scheel 1 collaboration

Awovi Didi Bedou 1 collaboration

Oliver Kluth 1 collaboration

Anett Helms 1 collaboration

Sarah Voß 1 collaboration

Thilo Speckmann 1 collaboration

Magnus R Larsen 1 collaboration

Dorte E Steenberg 1 collaboration

Janne R Hingst 1 collaboration

Kurt Højlund 1 collaboration

Atul S Deshmukh 1 collaboration

Angéline Geiser 1 collaboration

Susan Currie 1 collaboration

Gail McConnell 1 collaboration

Gwyn W Gould 1 collaboration

Anna Rita Minafra 1 collaboration

Puyan Rafii 1 collaboration

Kristina Behnke 1 collaboration

Kálmán Bódis 1 collaboration

Saida Breuer 1 collaboration

Assja Crepzia-Pevzner 1 collaboration

Oana-Patricia Zaharia 1 collaboration

Martin Schön 1 collaboration

Nina Saatmann 1 collaboration

Julia Szendroedi 1 collaboration

Robert Wagner 1 collaboration

Dominik Pesta 1 collaboration

None None 1 collaboration

Deborah Weide 1 collaboration

Anna Lena Cremer 1 collaboration

Heiko Backes 1 collaboration

Sebastian Sill 1 collaboration

Anette Kurowski 1 collaboration

Daebin Kim 1 collaboration

Sandra Karpinski 1 collaboration

Jens Brüning 1 collaboration

Matthias Lienhard 1 collaboration

Stefan Börno 1 collaboration

Bernd Timmermann 1 collaboration

Oleksiy Klymenko 1 collaboration

Tim Brecklinghaus 1 collaboration

Matthias Dille 1 collaboration

Christopher Hardt 1 collaboration

Paul T Pfluger 1 collaboration

Dhiraj G Kabra 1 collaboration

Heja Aga 1 collaboration

Markus Jaehnert 1 collaboration

Sophie Osburg 1 collaboration

Gunnar Schulze 1 collaboration

Gudrun Brockmann 1 collaboration

Emil Jørsboe 1 collaboration

Inger K Dahl-Petersen 1 collaboration

Jonas M Kristensen 1 collaboration

Peter Bjerregaard 1 collaboration

Søren Brage 1 collaboration

Oluf Pedersen 1 collaboration

Ida Moltke 1 collaboration

Niels Grarup 1 collaboration

Anders Albrechtsen 1 collaboration

Marit E Jørgensen 1 collaboration

D Margriet Ouwens 1 collaboration

Mareike Damen 1 collaboration

Georgia Lenihan-Geels 1 collaboration

Francisco Garcia Carrizo 1 collaboration

Marina Leer 1 collaboration

Sabrina Gohlke 1 collaboration

Moritz Oster 1 collaboration

Sophie Pöhle-Kronawitter 1 collaboration

Christiane Ott 1 collaboration

Isabel N Reinisch 1 collaboration

Markus Galhuber 1 collaboration

Chen Li 1 collaboration

Susanne Klaus 1 collaboration

Tilman Grune 1 collaboration

Tobias Madl 1 collaboration

Andreas Prokesch 1 collaboration

Michael Schupp 1 collaboration

Tim J Schulz 1 collaboration

Sayeed Ur Rehman 1 collaboration

Ben Leiser 1 collaboration

Viola Joschko 1 collaboration

Manopriya Chokkalingam 1 collaboration

Leon Peifer-Weiß 1 collaboration

Angela Pelligra 1 collaboration

Matthias Blüher 1 collaboration

Ralf Erkens 1 collaboration

Dragos Andrei Duse 1 collaboration

Amanda Brum 1 collaboration

Stefanie Becher 1 collaboration

Mauro Siragusa 1 collaboration

Christine Quast 1 collaboration

Johanna Müssig 1 collaboration

Miriam Cortese-Krott 1 collaboration

Borja Ibáñez 1 collaboration

Eckhard Lammert 1 collaboration

Ingrid Fleming 1 collaboration

Christian Jung 1 collaboration

Gerd Heusch 1 collaboration

Malte Kelm 1 collaboration

Isabel Zeinert 1 collaboration

Isabelle Sinowenka 1 collaboration

Frank Müller 1 collaboration

Christina Schöndeling 1 collaboration

Hannah Batchelor 1 collaboration

Zhou Zhou 1 collaboration

Kristin Schwerbel 1 collaboration

Natalie Krahmer 1 collaboration

Fabian Schumacher 1 collaboration

Burkhard Kleuser 1 collaboration

Tom Haltenhof 1 collaboration

Florian Heyd 1 collaboration

Sofiya Gancheva 1 collaboration

Karl W Broman 1 collaboration

Julie L W Roll 1 collaboration

Marc Foretz 1 collaboration

Benoit Viollet 1 collaboration

Sharon C Hook 1 collaboration

Kate J Heesom 1 collaboration

Shosei Kishida 1 collaboration

Jeremy M Tavaré 1 collaboration

Elaine C Thomas 1 collaboration

C Binsch 1 collaboration

D M Barbosa 1 collaboration

G Hansen-Dille 1 collaboration

M Hubert 1 collaboration

S M Hodge 1 collaboration

M Kolasa 1 collaboration

K Jeruschke 1 collaboration

J Weiß 1 collaboration

C Springer 1 collaboration

S Gorressen 1 collaboration

J W Fischer 1 collaboration

M Lienhard 1 collaboration

R Herwig 1 collaboration

S Börno 1 collaboration

B Timmermann 1 collaboration

A L Cremer 1 collaboration

H Backes 1 collaboration

A Chadt 1 collaboration

H Al-Hasani 1 collaboration

Kerstin Griess 1 collaboration

Bengt-Frederik Belgardt 1 collaboration

Jürgen Weiss 1 collaboration

Inka Rapöhn 1 collaboration

Ivet Elias 1 collaboration

Juliane Weiner 1 collaboration

Anna Pujol 1 collaboration

Stephanie Kehr 1 collaboration

Ralph Burkhardt 1 collaboration

Nora Klöting 1 collaboration

Michael Stumvoll 1 collaboration

Fatima Bosch 1 collaboration

Peter Kovacs 1 collaboration

John T Heiker 1 collaboration

Jana Breitfeld 1 collaboration