Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers.
Alcohol Drinking
/ epidemiology
Alcoholic Beverages
Australia
/ epidemiology
Case-Control Studies
Coffee
Diabetes Mellitus
/ epidemiology
Female
France
/ epidemiology
Germany
/ epidemiology
Humans
Liver Cirrhosis, Alcoholic
/ epidemiology
Logistic Models
Male
Marijuana Use
/ epidemiology
Medical History Taking
Middle Aged
Obesity
/ epidemiology
Risk Factors
Smoking
/ epidemiology
Switzerland
Tea
United Kingdom
/ epidemiology
United States
/ epidemiology
Wine
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
21
01
2020
accepted:
17
06
2020
pubmed:
2
9
2020
medline:
5
2
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
Sustained high alcohol intake is necessary but not sufficient to produce alcohol-related cirrhosis. Identification of risk factors, apart from lifetime alcohol exposure, would assist in discovery of mechanisms and prediction of risk. We conducted a multicenter case-control study (GenomALC) comparing 1,293 cases (with alcohol-related cirrhosis, 75.6% male) and 754 controls (with equivalent alcohol exposure but no evidence of liver disease, 73.6% male). Information confirming or excluding cirrhosis, and on alcohol intake and other potential risk factors, was obtained from clinical records and by interview. Case-control differences in risk factors discovered in the GenomALC participants were validated using similar data from 407 cases and 6,573 controls from UK Biobank. The GenomALC case and control groups reported similar lifetime alcohol intake (1,374 vs 1,412 kg). Cases had a higher prevalence of diabetes (20.5% (262/1,288) vs 6.5% (48/734), P = 2.27 × 10-18) and higher premorbid body mass index (26.37 ± 0.16 kg/m2) than controls (24.44 ± 0.18 kg/m2, P = 5.77 × 10-15). Controls were significantly more likely to have been wine drinkers, coffee drinkers, smokers, and cannabis users than cases. Cases reported a higher proportion of parents who died of liver disease than controls (odds ratio 2.25 95% confidence interval 1.55-3.26). Data from UK Biobank confirmed these findings for diabetes, body mass index, proportion of alcohol as wine, and coffee consumption. If these relationships are causal, measures such as weight loss, intensive treatment of diabetes or prediabetic states, and coffee consumption should reduce the risk of alcohol-related cirrhosis.
Identifiants
pubmed: 32868629
pii: 00000434-202101000-00022
doi: 10.14309/ajg.0000000000000833
doi:
Substances chimiques
Coffee
0
Tea
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106-115Subventions
Organisme : Medical Research Council
ID : MR/S000607/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 by The American College of Gastroenterology.
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