Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance.

Chromosome Aberrations Humans Myelodysplastic Syndromes / diagnosis Prognosis Retrospective Studies Translocation, Genetic
Myelodysplastic syndromes chromosomal translocations karyotype prognosis

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
12 2020
Historique:
pubmed: 2 9 2020
medline: 28 4 2021
entrez: 2 9 2020
Statut: ppublish

Résumé

Prognostic role of chromosomal translocations (CT) in myelodysplasia (MDS) was retrospectively analyzed in 77 patients from GROM-L registry. Forty (51.9%) balanced, 28 (36.4%) unbalanced and 9 (11.7%) concomitant balanced and unbalanced CT were identified. Five-year overall survival (OS) of the entire cohort was 34.5% (CI 95% 22.5-46.5). Five-year OS of patients with unbalanced CT was significantly shorter than that of patients carrying balanced CT [22.3% (CI 95% 4.0-40.6) vs 44.0% (CI 95% 26.7-61.3) (

Identifiants

DOI: 10.1080/10428194.2020.1811861 PMID: 32870062
pubmed: 32870062
doi: 10.1080/10428194.2020.1811861
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3476-3483

Auteurs

Sara Mohamed (S)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Roberto Latagliata (R)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Maria Zaira Limongi (MZ)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Stefania Nigro (S)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Eleonora Sangiorgi (E)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Mauro Nanni (M)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Annalina Piccioni (A)

Hematology, Azienda Ospedaliera S. Giovanni-Addolorata, Rome, Italy.

Alessia Campagna (A)

Hematology, Sant'Andrea Hospital Sapienza University of Rome, Rome, Italy.

Maria Antonietta Aloe Spiriti (MAA)

Hematology, Sant'Andrea Hospital Sapienza University of Rome, Rome, Italy.

Ida Carmosino (I)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Matteo Molica (M)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Elena Mariggiò (E)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Serena Rosati (S)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Gioia Colafigli (G)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Francesca Fazio (F)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Maria Lucia De Luca (ML)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Daniela De Benedittis (D)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Emilia Scalzulli (E)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Massimo Breccia (M)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

Marco Mancini (M)

Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I Sapienza University of Rome, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Aberrations des chromosomes › Balanced and unbalanced chromosomal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Balanced and unbalanced chromosomal...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Syndromes myélodysplasiques › Balanced and unbalanced chromosomal...
questionsmedicales.fr › Diagnostic › Pronostic › Balanced and unbalanced chromosomal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Balanced and unbalanced chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Translocation génétique › Balanced and unbalanced chromosomal...