Mapping QTL Associated with Resistance to Avian Oncogenic Marek's Disease Virus (MDV) Reveals Major Candidate Genes and Variants.
FSIL
GWAS
Marek’s disease virus
QTL
candidate gene
disease resistance
transcriptomics
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
30 08 2020
30 08 2020
Historique:
received:
02
08
2020
revised:
20
08
2020
accepted:
26
08
2020
entrez:
3
9
2020
pubmed:
3
9
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Marek's disease (MD) represents a significant global economic and animal welfare issue. Marek's disease virus (MDV) is a highly contagious oncogenic and highly immune-suppressive α-herpes virus, which infects chickens, causing neurological effects and tumour formation. Though partially controlled by vaccination, MD continues to have a profound impact on animal health and on the poultry industry. Genetic selection provides an alternative and complementary method to vaccination. However, even after years of study, the genetic mechanisms underlying resistance to MDV remain poorly understood. The Major Histocompatability Complex (MHC) is known to play a role in disease resistance, along with a handful of other non-MHC genes. In this study, one of the largest to date, we used a multi-facetted approach to identify QTL regions (QTLR) influencing resistance to MDV, including an F
Identifiants
pubmed: 32872585
pii: genes11091019
doi: 10.3390/genes11091019
pmc: PMC7564597
pii:
doi:
Substances chimiques
Genetic Markers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/K006916/1
Pays : United Kingdom
Références
Genes (Basel). 2019 Feb 05;10(2):
pubmed: 30764491
Anim Genet. 2013 Apr;44(2):217-22
pubmed: 22812605
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7
pubmed: 19474294
BMC Genomics. 2013 Jan 30;14:64
pubmed: 23363372
BMC Genomics. 2013 May 10;14:313
pubmed: 23663209
Vet Res. 2016 Nov 28;47(1):119
pubmed: 27894330
Poult Sci. 2005 Nov;84(11):1678-88
pubmed: 16463964
BMC Genomics. 2019 Mar 28;20(1):245
pubmed: 30922224
BMC Genomics. 2017 Apr 24;18(1):323
pubmed: 28438136
PLoS Biol. 2015 Jul 27;13(7):e1002198
pubmed: 26214839
Genetics. 2007 Dec;177(4):2417-31
pubmed: 18073438
Anim Genet. 2001 Dec;32(6):351-9
pubmed: 11736805
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Immunity. 2007 Dec;27(6):885-99
pubmed: 18083574
Avian Dis. 2013 Jun;57(2 Suppl):519-22
pubmed: 23901770
Prev Vet Med. 2014 Nov 15;117(2):358-66
pubmed: 25085600
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Cytogenet Genome Res. 2003;102(1-4):304-8
pubmed: 14970721
Vet J. 2005 Sep;170(2):175-83
pubmed: 16129338
Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13879-84
pubmed: 15356338
J Vet Sci. 2018 May 31;19(3):375-383
pubmed: 29366301
Nat Biotechnol. 2013 Jan;31(1):46-53
pubmed: 23222703
BMC Genomics. 2013 Jan 28;14:59
pubmed: 23356797
Genetics. 2004 Jan;166(1):611-9
pubmed: 15020448
Genet Sel Evol. 2016 Jan 07;48:1
pubmed: 26743767
J Virol. 2011 Nov;85(21):11146-58
pubmed: 21865384
Poult Sci. 2011 Jun;90(6):1206-11
pubmed: 21597060
Genetics. 1998 Jan;148(1):349-60
pubmed: 9475745
Avian Pathol. 2002 Oct;31(5):449-61
pubmed: 12427339
BMC Genomics. 2009 Jan 14;10:20
pubmed: 19144166
BMC Genomics. 2015 Apr 18;16:311
pubmed: 25896894
Poult Sci. 2015 Jun;94(6):1165-9
pubmed: 25840961
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9203-8
pubmed: 11470922
mBio. 2014 Jan 21;5(1):e01060-13
pubmed: 24449754
Curr Top Microbiol Immunol. 2001;255:57-90
pubmed: 11217428
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16740-5
pubmed: 19805366
DNA Res. 2015 Feb;22(1):53-67
pubmed: 25428896
Poult Sci. 1975 Nov;54(6):2066-8
pubmed: 180503
PLoS One. 2016 Apr 14;11(4):e0153423
pubmed: 27077383
J Natl Cancer Inst. 1967 Aug;39(2):267-80
pubmed: 18623944
Genes (Basel). 2019 Feb 05;10(2):
pubmed: 30764490
Genetics. 2001 Apr;157(4):1683-98
pubmed: 11290723
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Sci Rep. 2017 Aug 31;7(1):10294
pubmed: 28860661
Genes (Basel). 2019 Jan 22;10(2):
pubmed: 30678299
Fly (Austin). 2012 Apr-Jun;6(2):80-92
pubmed: 22728672
BMC Genomics. 2019 Feb 4;20(Suppl 1):79
pubmed: 30712509
Philos Trans R Soc Lond B Biol Sci. 2000 Aug 29;355(1400):1077-84
pubmed: 11186309
Genome Biol. 2013 Apr 25;14(4):R36
pubmed: 23618408
Genomics. 2012 Mar;99(3):152-9
pubmed: 22178800
PLoS One. 2012;7(7):e41849
pubmed: 22848633
Anim Genet. 1999 Apr;30(2):126-35
pubmed: 10376303
Avian Dis. 2010 Mar;54(1 Suppl):572-5
pubmed: 20521696
Poult Sci. 1981 Jun;60(6):1132-9
pubmed: 6267578
Avian Dis. 2013 Jun;57(2 Suppl):395-400
pubmed: 23901752
Dev Biol (Basel). 2008;132:365-372
pubmed: 18817328