Asian People
/ genetics
Biomarkers, Tumor
/ genetics
Case-Control Studies
Esophageal Neoplasms
/ epidemiology
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
India
/ epidemiology
Male
Membrane Glycoproteins
/ genetics
Middle Aged
Nerve Tissue Proteins
/ genetics
Polymorphism, Single Nucleotide
Prognosis
Survival Rate
Candidate gene
Jammu and Kashmir
case–control
esophageal cancer
leucine-rich repeat and fibronectin type 2
odds ratio
Journal
Journal of cancer research and therapeutics
ISSN: 1998-4138
Titre abrégé: J Cancer Res Ther
Pays: India
ID NLM: 101249598
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
4
9
2020
medline:
7
9
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
Leucine-rich repeat and fibronectin type 2 gene (LRFN2) variant rs2494938 has recently been found associated with esophageal cancer in a genome-wide association study in an Asian population. However, this association has not been replicated in any Indian population despite high incidence of the disease. In the present case-control study, 166 cases and 459 controls were included. Taqman assay technique using real-time PCR was employed to investigate the association of the variant with esophageal cancer in the population of Jammu and Kashmir (J&K). The Hardy-Weinberg equilibrium for rs2494938 was assessed using the Chi-square test. The allele- and genotype-specific risk was estimated by odds ratio (OR) with 95% confidence interval (CI). Variant rs2494938 was observed to be significantly associated with esophageal cancer with an allelic OR of 1.59 (1.23-2.04 at 95% CI, P = 0.0003). The study highlights LRFN2 as a candidate gene for esophageal cancer susceptibility in the population of J&K and calls for a detailed study with a large sample size and involving more ethnic groups of India.
Sections du résumé
BACKGROUND
BACKGROUND
Leucine-rich repeat and fibronectin type 2 gene (LRFN2) variant rs2494938 has recently been found associated with esophageal cancer in a genome-wide association study in an Asian population. However, this association has not been replicated in any Indian population despite high incidence of the disease.
MATERIALS AND METHODS
METHODS
In the present case-control study, 166 cases and 459 controls were included. Taqman assay technique using real-time PCR was employed to investigate the association of the variant with esophageal cancer in the population of Jammu and Kashmir (J&K). The Hardy-Weinberg equilibrium for rs2494938 was assessed using the Chi-square test. The allele- and genotype-specific risk was estimated by odds ratio (OR) with 95% confidence interval (CI).
RESULTS
RESULTS
Variant rs2494938 was observed to be significantly associated with esophageal cancer with an allelic OR of 1.59 (1.23-2.04 at 95% CI, P = 0.0003).
CONCLUSION
CONCLUSIONS
The study highlights LRFN2 as a candidate gene for esophageal cancer susceptibility in the population of J&K and calls for a detailed study with a large sample size and involving more ethnic groups of India.
Identifiants
pubmed: 32880595
pii: 283076
doi: 10.4103/jcrt.JCRT_613_19
doi:
Substances chimiques
Biomarkers, Tumor
0
LRFN2 protein, human
0
Membrane Glycoproteins
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
S156-S159Déclaration de conflit d'intérêts
None