Genome-Wide Linkage Analysis of the Risk of Contracting a Bloodstream Infection in 47 Pedigrees Followed for 23 Years Assembled From a Population-Based Cohort (the HUNT Study).
Adult
Aged
Aged, 80 and over
Chromosomes, Human, Pair 4
/ genetics
Cohort Studies
Female
Genetic Linkage
/ genetics
Genetic Loci
/ genetics
Genetic Predisposition to Disease
/ genetics
Genome-Wide Association Study
Humans
Male
Middle Aged
Norway
Pedigree
Polymorphism, Single Nucleotide
/ genetics
Risk Factors
Sepsis
/ etiology
Young Adult
Journal
Critical care medicine
ISSN: 1530-0293
Titre abrégé: Crit Care Med
Pays: United States
ID NLM: 0355501
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
pubmed:
5
9
2020
medline:
26
5
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
Bloodstream infection is an important cause of death worldwide. The main objective of this study was to identify genetic loci linked to risk of contracting a bloodstream infection. Genome-wide linkage analysis. Population-based, Norwegian cohort, followed between 1995 and 2017. Among 69,423 genotyped subjects, there were 47 families with two or more second-degree relatives with bloodstream infection in the follow-up period. There were 365 subjects in these families, of which 110 were affected. None. The cohort was genotyped using Illumina HumanCoreExome (Illumina, San Diego, CA) arrays. Before linkage analysis, single-nucleotide polymorphisms were pruned and clumped. In nonparametric linkage analysis using an exponential model, we found three loci with a suggestive linkage to bloodstream infection, all on chromosome 4, at 46.6 centimorgan (logarithm of odds, 2.3), 57.7 centimorgan (logarithm of odds, 3.2), and 70.0 centimorgan (logarithm of odds, 2.1). At the peak of the lead region are three genes: TLR10, TLR1, and TLR6. Variations in the TLR10/1/6 locus appear to be linked with the risk of contracting a bloodstream infection.
Identifiants
pubmed: 32885941
doi: 10.1097/CCM.0000000000004520
pii: 00003246-202011000-00005
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1580-1586Commentaires et corrections
Type : CommentIn
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