Genetic variants in the glucocorticoid pathway genes and birth weight.
Adult
Birth Weight
Cohort Studies
Female
Genotype
Glucocorticoids
/ genetics
Haplotypes
Humans
Hypothalamo-Hypophyseal System
/ metabolism
Infant, Newborn
Male
Pituitary-Adrenal System
/ metabolism
Polymorphism, Single Nucleotide
Pregnancy
Receptors, Corticotropin-Releasing Hormone
/ genetics
Receptors, Glucocorticoid
/ genetics
Tacrolimus Binding Proteins
/ genetics
Birth weight
CRHR1
FKBP5
NR3C1
Single nucleotide polymorphisms
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
20
02
2020
accepted:
24
08
2020
pubmed:
5
9
2020
medline:
16
3
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
The aim of this study was to examine associations between single nucleotide polymorphisms (SNPs) that tag genetic variation in the glucocorticoid pathways (particularly in maternal genes FKBP5, NR3C1, and CRHR1) and birth weight. The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for the assessment of maternal and fetal health. Germline DNA was collected from 375 pregnant women. Nine SNPs in the above-mentioned genes were genotyped. After reconstruction of haplotypes for each gene, a linear regression model was applied to the data to describe the association between haplotypes and birth weight. Female sex in the newborn (compared to male) was associated with lower birth weight, whereas a later week of gestation, higher body mass index pre-pregnancy, and higher parity were associated with higher birth weight. No association with birthweight was shown for the haplotypes of the selected SNPs. In this cohort of healthy unselected pregnant women, the analyzed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show any association with birth weight. This might be in line with several other studies that have found no influence of fetal polymorphisms in the glucocorticoid receptor gene or triggers of the maternal HPA axis such as stress and psychosocial problems on birth weight. However, the small sample size in this study and the lack of consideration of individual risk factors and levels of stress in this cohort needs to be taken into account when interpreting the results.
Identifiants
pubmed: 32886236
doi: 10.1007/s00404-020-05761-6
pii: 10.1007/s00404-020-05761-6
doi:
Substances chimiques
Glucocorticoids
0
NR3C1 protein, human
0
Receptors, Corticotropin-Releasing Hormone
0
Receptors, Glucocorticoid
0
CRF receptor type 1
5CLY6W2H1M
Tacrolimus Binding Proteins
EC 5.2.1.-
tacrolimus binding protein 5
EC 5.2.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
427-434Références
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