Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction.

ADAMTS Proteins / genetics Carotid Artery Diseases / complications Chromosomes / genetics Cohort Studies Coronary Artery Disease / genetics Coronary Vessel Anomalies / genetics Female Fibromuscular Dysplasia / complications Genes, Neoplasm Genome-Wide Association Study Humans Low Density Lipoprotein Receptor-Related Protein-1 / genetics Male Meta-Analysis as Topic Microfilament Proteins / genetics Myocardial Infarction / genetics Risk Factors Vascular Diseases / congenital

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
04 09 2020
Historique:
received: 29 12 2019
accepted: 26 06 2020
entrez: 5 9 2020
pubmed: 6 9 2020
medline: 30 9 2020
Statut: epublish

Résumé

Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook a genome-wide association study of SCAD (N

Identifiants

DOI: 10.1038/s41467-020-17558-x PMID: 32887874 PMC: PMC7474092
pubmed: 32887874
doi: 10.1038/s41467-020-17558-x
pii: 10.1038/s41467-020-17558-x
pmc: PMC7474092
doi:

Substances chimiques

ADAMTSL4 protein, human 0
LRP1 protein, human 0
Low Density Lipoprotein Receptor-Related Protein-1 0
Microfilament Proteins 0
PHACTR1 protein, human 0
ADAMTS Proteins EC 3.4.24.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

4432

Subventions

Organisme : BLRD VA
ID : I01 BX004821
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128300
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122684
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL147823
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL103866
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL086694
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL076491
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139672
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG009124
Pays : United States
Organisme : BLRD VA
ID : I01 BX003362
Pays : United States
Organisme : CIHR
ID : 136799
Pays : Canada
Organisme : NCRR NIH HHS
ID : UL1 RR024989
Pays : United States

Investigateurs

Themistocles L Assimes (TL)
Christopher J O'Donnell (CJ)

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Auteurs

Jacqueline Saw (J)

Vancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada. jsaw@mail.ubc.ca.
ORCID: 0000-0002-7027-984X

Min-Lee Yang (ML)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.

Mark Trinder (M)

Vancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada.
Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Catherine Tcheandjieu (C)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Department of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA, USA.

Chang Xu (C)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Andrew Starovoytov (A)

Vancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada.

Isabelle Birt (I)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
ORCID: 0000-0002-9909-1154

Michael R Mathis (MR)

Department of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-9697-2212

Kristina L Hunker (KL)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.

Ellen M Schmidt (EM)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0003-1198-7536

Linda Jackson (L)

Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Natalia Fendrikova-Mahlay (N)

Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Matthew Zawistowski (M)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-3005-083X

Chad M Brummett (CM)

Department of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Sebastian Zoellner (S)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Alexander Katz (A)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
ORCID: 0000-0001-9706-9490

Dawn M Coleman (DM)

Vascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

Kirby Swan (K)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
ORCID: 0000-0002-3501-204X

Christopher J O'Donnell (CJ)

VA Boston Healthcare System, Boston, MA, USA.
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
ORCID: 0000-0002-2667-8624

Xiang Zhou (X)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-4331-7599

Jun Z Li (JZ)

Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
ORCID: 0000-0001-6727-0812

Heather L Gornik (HL)

Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Themistocles L Assimes (TL)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0003-2349-0009

James C Stanley (JC)

Vascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

Liam R Brunham (LR)

Vancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada.
Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
ORCID: 0000-0002-3686-3807

Santhi K Ganesh (SK)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. sganesh@umich.edu.
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA. sganesh@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Protéines ADAMTS › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Artériopathies carotidiennes › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Maladie des artères coronaires › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Cardiopathies congénitales › Anomalies congénitales des vaisseaux coronaires › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Dysplasie fibromusculaire › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Protéines apparentées au récepteur LDL › Protéine-1 apparentée au récepteur des LDL › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méta-analyse comme sujet › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Chromosome 1q21.2 and additional loci...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Chromosome 1q21.2 and additional loci...