Efficacy of a weight loss program prior to robot assisted radical prostatectomy in overweight and obese men with prostate cancer.
Aged
Aged, 80 and over
Blood Pressure
Body Mass Index
Exercise
Humans
Male
Middle Aged
Obesity
Overweight
/ physiopathology
Postoperative Complications
/ epidemiology
Preoperative Care
/ methods
Prostatic Neoplasms
/ surgery
Retrospective Studies
Robotic Surgical Procedures
Treatment Outcome
Weight Loss
Weight Reduction Programs
/ methods
Western Australia
/ epidemiology
Prostate cancer
Radical prostatectomy
Weight loss
Journal
Surgical oncology
ISSN: 1879-3320
Titre abrégé: Surg Oncol
Pays: Netherlands
ID NLM: 9208188
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
27
03
2020
revised:
03
07
2020
accepted:
02
08
2020
pubmed:
6
9
2020
medline:
12
10
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
Obesity in prostate cancer patients is associated with poor prostate-cancer specific outcomes. Exercise and nutrition can reduce fat mass; however, few studies have explored this as a combined pre-surgical intervention in clinical practice. This study examined the efficacy of a weight loss program for altering body composition in prostate cancer patients prior to robot assisted radical prostatectomy (RARP). A retrospective analysis of 43 overweight and obese prostate cancer patients, aged 47-80 years, who completed a very low-calorie diet (~3000-4000 kJ) combined with moderate-intensity exercise (90 min/day) prior to RARP. Whole body and regional fat mass (FM) and lean mass (LM) were assessed by dual-energy x-ray absorptiometry pre- and post-program. Body weight, waist circumference, and blood pressure were assessed weekly, with surgery-related adverse effects recorded at time of surgery and follow-up appointments. With a median of 29 days (IQR: 24-35days) on the program, patients significantly (p < 0.001) reduced weight (-7.3 ± 2.9 kg), FM (-5.0 ± 2.6 kg), percent body fat (-3.1 ± 2.5%), trunk FM (-3.4 ± 1.8 kg), LM (-2.4 ± 1.8 kg), and appendicular LM (-1.2 ± 1.0 kg). Lower weight, FM, percent FM, trunk FM, and visceral FM were associated with less surgery-related adverse effects (r Undertaking a combined low-calorie diet and exercise program for weight loss in preparation for RARP resulted in substantial reductions in FM, with improvements in blood pressure, that may benefit surgical outcomes.
Sections du résumé
BACKGROUND
BACKGROUND
Obesity in prostate cancer patients is associated with poor prostate-cancer specific outcomes. Exercise and nutrition can reduce fat mass; however, few studies have explored this as a combined pre-surgical intervention in clinical practice.
PURPOSE
OBJECTIVE
This study examined the efficacy of a weight loss program for altering body composition in prostate cancer patients prior to robot assisted radical prostatectomy (RARP).
METHODS
METHODS
A retrospective analysis of 43 overweight and obese prostate cancer patients, aged 47-80 years, who completed a very low-calorie diet (~3000-4000 kJ) combined with moderate-intensity exercise (90 min/day) prior to RARP. Whole body and regional fat mass (FM) and lean mass (LM) were assessed by dual-energy x-ray absorptiometry pre- and post-program. Body weight, waist circumference, and blood pressure were assessed weekly, with surgery-related adverse effects recorded at time of surgery and follow-up appointments.
RESULTS
RESULTS
With a median of 29 days (IQR: 24-35days) on the program, patients significantly (p < 0.001) reduced weight (-7.3 ± 2.9 kg), FM (-5.0 ± 2.6 kg), percent body fat (-3.1 ± 2.5%), trunk FM (-3.4 ± 1.8 kg), LM (-2.4 ± 1.8 kg), and appendicular LM (-1.2 ± 1.0 kg). Lower weight, FM, percent FM, trunk FM, and visceral FM were associated with less surgery-related adverse effects (r
CONCLUSION
CONCLUSIONS
Undertaking a combined low-calorie diet and exercise program for weight loss in preparation for RARP resulted in substantial reductions in FM, with improvements in blood pressure, that may benefit surgical outcomes.
Identifiants
pubmed: 32889251
pii: S0960-7404(20)30349-2
doi: 10.1016/j.suronc.2020.08.006
pii:
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
182-188Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.