Race, APOL1 Risk Variants, and Clinical Outcomes among Older Adults: The ARIC Study.
Black or African American
/ genetics
Aged
Albuminuria
/ ethnology
Alleles
Apolipoprotein L1
/ genetics
Cohort Studies
Creatinine
/ blood
Cystatin C
/ blood
Female
Glomerular Filtration Rate
Humans
Independent Living
Kidney Failure, Chronic
/ epidemiology
Longitudinal Studies
Male
Mortality
/ ethnology
Racial Groups
/ statistics & numerical data
Renal Insufficiency, Chronic
/ epidemiology
United States
/ epidemiology
White People
/ genetics
APOL1
apolipoprotein L1
chronic kidney disease
end-stage renal disease
mortality
Journal
Journal of the American Geriatrics Society
ISSN: 1532-5415
Titre abrégé: J Am Geriatr Soc
Pays: United States
ID NLM: 7503062
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
30
04
2020
revised:
31
07
2020
accepted:
03
08
2020
pubmed:
8
9
2020
medline:
15
9
2021
entrez:
7
9
2020
Statut:
ppublish
Résumé
APOL1 high-risk genotypes confer an increased risk for kidney disease, but their clinical significance among older adults remains unclear. We aimed to determine whether APOL1 genotype status (high risk = 2 risk alleles; low risk = 0-1 risk alleles) and self-reported race (Black; White) are associated with number of hospitalizations, incident chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality among older adults participating in a community-based cohort study. Observational longitudinal cohort study. The Atherosclerosis Risk in Communities (ARIC) study. Community-dwelling older adults (mean age = 75.8 years; range = 66-90 years). Among 5,564 ARIC participants (78.2% White, 19.1% APOL1 low-risk Black, and 2.7% APOL1 high-risk Black), the proportion with creatinine and cystatin C-based estimated glomerular filtration rate (eGFR Among older Black adults, APOL1 high-risk genotypes were associated with lower kidney function and therefore higher risk of ESRD. Racial disparities in incident kidney disease persisted in older age and were not fully explained by APOL1.
Sections du résumé
BACKGROUND/OBJECTIVES
APOL1 high-risk genotypes confer an increased risk for kidney disease, but their clinical significance among older adults remains unclear. We aimed to determine whether APOL1 genotype status (high risk = 2 risk alleles; low risk = 0-1 risk alleles) and self-reported race (Black; White) are associated with number of hospitalizations, incident chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality among older adults participating in a community-based cohort study.
DESIGN
Observational longitudinal cohort study.
SETTING
The Atherosclerosis Risk in Communities (ARIC) study.
PARTICIPANTS
Community-dwelling older adults (mean age = 75.8 years; range = 66-90 years).
RESULTS
Among 5,564 ARIC participants (78.2% White, 19.1% APOL1 low-risk Black, and 2.7% APOL1 high-risk Black), the proportion with creatinine and cystatin C-based estimated glomerular filtration rate (eGFR
CONCLUSION
Among older Black adults, APOL1 high-risk genotypes were associated with lower kidney function and therefore higher risk of ESRD. Racial disparities in incident kidney disease persisted in older age and were not fully explained by APOL1.
Identifiants
pubmed: 32894582
doi: 10.1111/jgs.16797
pmc: PMC7855571
mid: NIHMS1659239
doi:
Substances chimiques
APOL1 protein, human
0
Apolipoprotein L1
0
Cystatin C
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
155-163Subventions
Organisme : NIDDK NIH HHS
ID : R01DK108803
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK089174
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079310
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK117068
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108803
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01DK089174
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004C
Pays : United States
Organisme : NIH HHS
ID : Under Award Number NIDDK P30DK079310
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08DK117068
Pays : United States
Informations de copyright
© 2020 The American Geriatrics Society.
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