Efficacy of generic meropenem products in combination with colistin in carbapenemase-producing Klebsiella pneumoniae experimental osteomyelitis.

Animals Bacterial Proteins / metabolism Carbapenem-Resistant Enterobacteriaceae / drug effects Colistin / therapeutic use Disease Models, Animal Drug Resistance, Multiple, Bacterial Drug Therapy, Combination Drugs, Generic / pharmacokinetics Klebsiella Infections / drug therapy Klebsiella pneumoniae / drug effects Meropenem / blood Microbial Sensitivity Tests Osteomyelitis / drug therapy Rabbits Therapeutic Equivalency beta-Lactamases / metabolism
Carbapenemase Colistin Generics Klebsiella pneumoniae Meropenem Osteomyelitis

Journal

International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 05 01 2020
revised: 06 08 2020
accepted: 29 08 2020
pubmed: 9 9 2020
medline: 7 7 2021
entrez: 8 9 2020
Statut: ppublish

Résumé

Guidelines for the management of carbapenemase-producing Enterobacterales (CPE) infections recommend a combination of two active agents, including meropenem if the minimum inhibitory concentration (MIC) is ≤8 mg/L. The therapeutic equivalence of meropenem generics has been challenged. We compared the bactericidal activity of meropenem innovator (AstraZeneca) and four generic products (Actavis, Kabi, Mylan and Panpharma), both in vitro and in vivo, in association with colistin. In vitro time-kill studies were performed at 4 × MIC. An experimental model of KPC-producing Klebsiella pneumoniae osteomyelitis was induced in rabbits by tibial injection of a sclerosing agent followed by 2 × 10

Identifiants

DOI: 10.1016/j.ijantimicag.2020.106152 PMID: 32898684
pubmed: 32898684
pii: S0924-8579(20)30351-4
doi: 10.1016/j.ijantimicag.2020.106152
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Drugs, Generic 0
beta-Lactamases EC 3.5.2.6
carbapenemase EC 3.5.2.6
Meropenem FV9J3JU8B1
Colistin Z67X93HJG1

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106152

Informations de copyright

Copyright © 2020 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.

Auteurs

P Tattevin (P)

Pontchaillou Univ. Hosp., Rennes, France; INSERM U1230, Université Rennes 1, IFR140, F-35033, Rennes, France. Electronic address: pierre.tattevin@chu-rennes.fr.

A Dinh (A)

UMR 1173, Versailles Saint-Quentin Université, Versailles, France; Raymond Poincaré Univ. Hosp., Garches, France.

I Ghout (I)

Ambroise Paré Univ. Hosp., Boulogne, France.

W Mouton (W)

Lyon Univ. Hosp., Lyon, France.

M-C Verdier (MC)

Pontchaillou Univ. Hosp., Rennes, France; INSERM CIC 1414, Université Rennes 1, F-35033, Rennes, France.

F Laurent (F)

Lyon Univ. Hosp., Lyon, France.

F Lemaitre (F)

Pontchaillou Univ. Hosp., Rennes, France; INSERM CIC 1414, Université Rennes 1, F-35033, Rennes, France.

L Gatin (L)

UMR 1173, Versailles Saint-Quentin Université, Versailles, France; Raymond Poincaré Univ. Hosp., Garches, France.

A Saleh-Mghir (A)

UMR 1173, Versailles Saint-Quentin Université, Versailles, France.

A-C Crémieux (AC)

UMR 1173, Versailles Saint-Quentin Université, Versailles, France; St Louis Hospital AP-HP, Université, Paris 7, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Efficacy of generic meropenem products in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Efficacy of generic meropenem products in...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Enterobacteriaceae résistantes aux carbapénèmes › Efficacy of generic meropenem products in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Polymyxines › Colistine › Efficacy of generic meropenem products in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Efficacy of generic meropenem products in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Efficacy of generic meropenem products in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Efficacy of generic meropenem products in...
questionsmedicales.fr › Préparations pharmaceutiques › Médicaments génériques › Efficacy of generic meropenem products in...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Klebsiella › Efficacy of generic meropenem products in...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › Efficacy of generic meropenem products in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Thiénamycine › Méropénème › Efficacy of generic meropenem products in...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Efficacy of generic meropenem products in...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Infections osseuses › Ostéomyélite › Efficacy of generic meropenem products in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Efficacy of generic meropenem products in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Équivalence thérapeutique › Efficacy of generic meropenem products in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Efficacy of generic meropenem products in...