Morpholino Analogues of Fingolimod as Novel and Selective S1P
Animals
CHO Cells
Central Nervous System
/ drug effects
Cricetulus
Disease Models, Animal
Encephalomyelitis
/ drug therapy
Encephalomyelitis, Autoimmune, Experimental
/ drug therapy
Fingolimod Hydrochloride
/ analogs & derivatives
Immunosuppressive Agents
/ therapeutic use
Ligands
Lymphopenia
/ drug therapy
Lysophospholipids
/ metabolism
Mice
Morpholinos
/ pharmacology
Multiple Sclerosis
/ drug therapy
Receptors, Lysosphingolipid
/ metabolism
Sphingosine
/ analogs & derivatives
Sphingosine-1-Phosphate Receptors
/ drug effects
Spinal Cord
/ drug effects
T-Lymphocytes
/ drug effects
ST-1893
ST-1894
experimental antigen-induced encephalomyelitis
immunomodulator
lymphopenia
morpholino analogues of fingolimod
multiple sclerosis
sphingosine 1-phosphate
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Sep 2020
04 Sep 2020
Historique:
received:
03
08
2020
revised:
29
08
2020
accepted:
01
09
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
11
3
2021
Statut:
epublish
Résumé
Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune disease of the central nervous system (CNS) which is associated with lower life expectancy and disability. The experimental antigen-induced encephalomyelitis (EAE) in mice is a useful animal model of MS, which allows exploring the etiopathogenetic mechanisms and testing novel potential therapeutic drugs. A new therapeutic paradigm for the treatment of MS was introduced in 2010 through the sphingosine 1-phosphate (S1P) analogue fingolimod (FTY720, Gilenya
Identifiants
pubmed: 32899717
pii: ijms21186463
doi: 10.3390/ijms21186463
pmc: PMC7555234
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Ligands
0
Lysophospholipids
0
Morpholinos
0
Receptors, Lysosphingolipid
0
Sphingosine-1-Phosphate Receptors
0
sphingosine 1-phosphate
26993-30-6
Fingolimod Hydrochloride
G926EC510T
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 310030_135619
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK2158, INST 208/690-1
Organisme : European Cooperation in Science and Technology
ID : CA15135 and CA18240
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