Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children.
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
02 Sep 2020
02 Sep 2020
Historique:
entrez:
10
9
2020
pubmed:
11
9
2020
medline:
11
9
2020
Statut:
epublish
Résumé
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and multiple organ involvement in individuals under 21 years following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To identify genes, pathways and cell types driving MIS-C, we sequenced the blood transcriptomes of MIS-C cases, pediatric cases of coronavirus disease 2019, and healthy controls. We define a MIS-C transcriptional signature partially shared with the transcriptional response to SARS-CoV-2 infection and with the signature of Kawasaki disease, a clinically similar condition. By projecting the MIS-C signature onto a co-expression network, we identified disease gene modules and found genes downregulated in MIS-C clustered in a module enriched for the transcriptional signatures of exhausted CD8
Identifiants
pubmed: 32909006
doi: 10.1101/2020.08.29.20182899
pmc: PMC7480058
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL135742
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK124165
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA224319
Pays : United States
Investigateurs
Charuta Agashe
(C)
Priyal Agrawal
(P)
Eziwoma Alibo
(E)
Kelvin Alvarez
(K)
Angelo Amabile
(A)
Steven Ascolillo
(S)
Rasheed Bailey
(R)
Priya Begani
(P)
Cansu Cimen Bozkus
(CC)
Stacey-Ann Brown
(SA)
Mark Buckup
(M)
Larissa Burka
(L)
Lena Cambron
(L)
Gina Carrara
(G)
Serena Chang
(S)
Steven T Chen
(ST)
Jonathan Chien
(J)
Mashkura Chowdhury
(M)
Jonathan Chung
(J)
Paloma Bravo Correra
(PB)
Dana Cosgrove
(D)
Francesca Cossarini
(F)
Arpit Dave
(A)
Travis Dawson
(T)
Bheesham Dayal
(B)
Maxime Dhainaut
(M)
Rebecca Dornfeld
(R)
Katie Dul
(K)
Nissan Eber
(N)
Frank Fabris
(F)
Jeremiah Faith
(J)
Dominique Falci
(D)
Susie Feng
(S)
Marie Fernandes
(M)
Daniel Geanon
(D)
Joanna Grabowska
(J)
Gavin Gyimesi
(G)
Maha Hamdani
(M)
Diana Handler
(D)
Manon Herbinet
(M)
Elva Herrera
(E)
Arielle Hochman
(A)
Jaime Hook
(J)
Laila Horta
(L)
Etienne Humblin
(E)
Jessica S Johnson
(JS)
Subha Karim
(S)
Geoffrey Kelly
(G)
Jessica Kim
(J)
Dannielle Lebovitch
(D)
Brian Lee
(B)
Grace Lee
(G)
Gyu Ho Lee
(GH)
Jacky Lee
(J)
John Leech
(J)
Michael B Leventhal
(MB)
Katherine Lindblad
(K)
Alexandra Livanos
(A)
Rosalie Machado
(R)
Zafar Mahmood
(Z)
Kelcey Mar
(K)
Glenn Martin
(G)
Shrisha Maskey
(S)
Paul Matthews
(P)
Katherine Meckel
(K)
Saurabh Mehandru
(S)
Cynthia Mercedes
(C)
Dara Meyer
(D)
Gurkan Mollaoglu
(G)
Sarah Morris
(S)
Kai Nie
(K)
Marjorie Nisenholtz
(M)
Merouane Ounadjela
(M)
Vishwendra Patel
(V)
Cassandra Pruitt
(C)
Shivani Rathi
(S)
Jamie Redes
(J)
Ivan Reyes-Torres
(I)
Alcina Rodrigues
(A)
Alfonso Rodriguez
(A)
Vladimir Roudko
(V)
Evelyn Ruiz
(E)
Pearl Scalzo
(P)
Alessandra Soares Schanoski
(AS)
Pedro Silva
(P)
Hiyab Stefanos
(H)
Meghan Straw
(M)
Collin Teague
(C)
Bhaskar Upadhyaya
(B)
Verena Van Der Heide
(V)
Natalie Vaninov
(N)
Daniel Wacker
(D)
Hadley Walsh
(H)
C Matthias Wilk
(CM)
Jessica Wilson
(J)
Li Xue
(L)
Naa-Akomaah Yeboah
(NA)
Sabina Young
(S)
Nina Zaks
(N)
Renyuan Zha
(R)
Commentaires et corrections
Type : UpdateIn
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