Probing hepatic metabolism of [2-
Carbon-13 magnetic resonance spectroscopy
Dynamic Nuclear Polarisation
Gluconeogenesis
Glycolysis
Hyperpolarisation
Liver
Metabolism
Journal
Magma (New York, N.Y.)
ISSN: 1352-8661
Titre abrégé: MAGMA
Pays: Germany
ID NLM: 9310752
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
01
06
2020
accepted:
27
08
2020
revised:
07
08
2020
pubmed:
11
9
2020
medline:
18
9
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
To enhance detection of the products of hyperpolarized [2- Real-time hepatic metabolism of three fed mice was probed by The metabolic products detected in vivo include glycerol 3-phosphate, glycerol, phosphoenolpyruvate, lactate, alanine, glyceraldehyde 3-phosphate and glucose 6-phosphate. The metabolite-to-substrate ratios were comparable to those reported previously in perfused liver. Three metabolic pathways can be probed simultaneously in the mouse liver in vivo, in real time, using hyperpolarized DHAc.
Identifiants
pubmed: 32910316
doi: 10.1007/s10334-020-00884-y
pii: 10.1007/s10334-020-00884-y
pmc: PMC7910257
mid: EMS94968
doi:
Substances chimiques
Carbon Isotopes
0
Protons
0
Dihydroxyacetone
O10DDW6JOO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-56Subventions
Organisme : European Research Council
ID : 682574
Pays : International
Organisme : British Heart Foundation
ID : FS/19/18/34252
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0601490
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/14/17/30634
Pays : United Kingdom
Organisme : Engineering and Physical Sciences Research Council
ID : 16465
Organisme : Cancer Research UK
ID : 17242
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/7/31843
Pays : United Kingdom
Organisme : "la Caixa" Foundation
ID : LCF/BQ/PI18/11630020
Organisme : British Heart Foundation
ID : FS/10/002/28078
Pays : United Kingdom
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