Polyphenols vs. Coronaviruses: How Far Has Research Moved Forward?
3-chymotrypsin-like protease
antiviral activity
coronavirus
herbal extracts
papain-like protease
polyphenols
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
08 Sep 2020
08 Sep 2020
Historique:
received:
24
07
2020
revised:
03
09
2020
accepted:
07
09
2020
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
22
9
2020
Statut:
epublish
Résumé
The epidemic, caused by SARS-CoV-2 at the beginning of 2020, led us to a serious change in our lifestyle that for about three months has confined us to our homes, far from our laboratory routine. In this period, the belief that the work of a researcher should never stop has been the driving force in writing the present paper. It aims at reviewing the recent scientific knowledge about in vitro experimental data that focused on the antiviral role of phenols and polyphenols against different species of coronaviruses (CoVs), pointing up the viral targets potentially involved. In the current literature scenario, the papain-like and the 3-chymotrypsin-like proteases seem to be the most deeply investigated and a number of isolated natural (poly)phenols has been screened for their efficacy.
Identifiants
pubmed: 32911757
pii: molecules25184103
doi: 10.3390/molecules25184103
pmc: PMC7570460
pii:
doi:
Substances chimiques
Antiviral Agents
0
Polyphenols
0
Chymases
EC 3.4.21.39
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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