Griseococcin (1) from Bovistella radicata (Mont.) Pat and antifungal activity.
Agaricales
/ chemistry
Anti-Bacterial Agents
/ chemistry
Antifungal Agents
/ chemistry
Arthrodermataceae
/ drug effects
Bacteria
/ drug effects
Chromatography, High Pressure Liquid
Drug Evaluation, Preclinical
Fermentation
Fungi
/ drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Secondary Metabolism
Spectroscopy, Fourier Transform Infrared
1D NMR
2D NMR
DEAE
FT-IR
Griseococcin
HPLC
LH-20
Journal
BMC microbiology
ISSN: 1471-2180
Titre abrégé: BMC Microbiol
Pays: England
ID NLM: 100966981
Informations de publication
Date de publication:
10 09 2020
10 09 2020
Historique:
received:
14
05
2020
accepted:
01
09
2020
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
4
9
2021
Statut:
epublish
Résumé
To evaluate the antimicrobial and microbicidel activity of B. radicata fermentation broth, the broth was purified by DEAE-cellulose and sephadex LC-20 column. The compounds were submitted to spectral analyses (HPLC, FT-IR, 1D and 2D NMR etc.). The purified compounds were identified as the Griseococcin(s) which were naphthoquinone derivatives, the Chemical formula and MW of Griseococcin (1) was determined as C In this paper, the secondary metabolite compound Griseococcin (1) from B. radicata was purified. The purified compound can restrain main pathogens (T. rubrum and T. mentagrophytes) leading to tinea pedis. The antifungal activity of Griseococcin (1) was similar to that of the positive control and the fungicidal effect of Griseococcin (1) was better than that of positive control, it might be suitable for pharmaceutical industries.
Sections du résumé
BACKGROUND
To evaluate the antimicrobial and microbicidel activity of B. radicata fermentation broth, the broth was purified by DEAE-cellulose and sephadex LC-20 column. The compounds were submitted to spectral analyses (HPLC, FT-IR, 1D and 2D NMR etc.).
RESULTS
The purified compounds were identified as the Griseococcin(s) which were naphthoquinone derivatives, the Chemical formula and MW of Griseococcin (1) was determined as C
CONCLUSIONS
In this paper, the secondary metabolite compound Griseococcin (1) from B. radicata was purified. The purified compound can restrain main pathogens (T. rubrum and T. mentagrophytes) leading to tinea pedis. The antifungal activity of Griseococcin (1) was similar to that of the positive control and the fungicidal effect of Griseococcin (1) was better than that of positive control, it might be suitable for pharmaceutical industries.
Identifiants
pubmed: 32912139
doi: 10.1186/s12866-020-01961-x
pii: 10.1186/s12866-020-01961-x
pmc: PMC7488052
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
276Subventions
Organisme : National Natural Science Foundation of China
ID : 31371844
Pays : International
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