Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells.
aryl hydrocarbon receptor
colon cancer
progenitor cells
stem cells
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
20
12
2019
revised:
28
06
2020
accepted:
02
07
2020
pubmed:
12
9
2020
medline:
7
4
2021
entrez:
11
9
2020
Statut:
ppublish
Résumé
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that senses xenobiotics, diet, and gut microbial-derived metabolites, is increasingly recognized as a key regulator of intestinal biology. However, its effects on the function of colonic stem and progenitor cells remain largely unexplored. Here, we observed that inducible deletion of AhR in Lgr5
Identifiants
pubmed: 32915464
doi: 10.15252/embj.2019104319
pmc: PMC7527924
doi:
Substances chimiques
FOXM1 protein, human
0
Forkhead Box Protein M1
0
Foxm1 protein, mouse
0
Receptors, Aryl Hydrocarbon
0
Banques de données
SRA
['SRP159285']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e104319Subventions
Organisme : NCI NIH HHS
ID : R25 CA090301
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025713
Pays : United States
Organisme : Cancer Prevention and Research Institute of Texas (CPRIT)
ID : RP160589
Organisme : NCI NIH HHS
ID : R01 CA202697
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES029067
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA090301
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197707
Pays : United States
Informations de copyright
© 2020 The Authors.
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