Nucleosomes Meet Their Remodeler Match.

DNA / metabolism DNA Repair DNA Replication Nucleosomes / metabolism RNA / metabolism
ATP-dependent chromatin-remodeling factor DNA accessibility cryo-EM nucleosome

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
01 2021
Historique:
received: 17 06 2020
revised: 12 08 2020
accepted: 14 08 2020
pubmed: 13 9 2020
medline: 8 7 2021
entrez: 12 9 2020
Statut: ppublish

Résumé

Over 85% of all genomic DNA in eukaryotes is organized in arrays of nucleosomes, the basic organizational principle of chromatin. The tight interaction of DNA with histones represents a significant barrier for all DNA-dependent machineries. This is in part overcome by enzymes, termed ATP-dependent remodelers, that are recruited to nucleosomes at defined locations and modulate their structure. There are several different classes of remodelers, and all use specific nucleosome features to bind to and alter nucleosomes. This review highlights and summarizes areas of interactions with the nucleosome that allow remodeling to occur.

Identifiants

DOI: 10.1016/j.tibs.2020.08.010 PMID: 32917506
pubmed: 32917506
pii: S0968-0004(20)30207-3
doi: 10.1016/j.tibs.2020.08.010
pii:
doi:

Substances chimiques

Nucleosomes 0
RNA 63231-63-0
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

41-50

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Jonathan Markert (J)

Department of Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.

Karolin Luger (K)

Department of Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: karolin.luger@colorado.edu.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Nucleosomes Meet Their Remodeler Match.
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Nucleosomes Meet Their Remodeler Match.
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Nucleosomes Meet Their Remodeler Match.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Nucléosomes › Nucleosomes Meet Their Remodeler Match.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Nucleosomes Meet Their Remodeler Match.