Effects of complement gene-set polygenic risk score on brain volume and cortical measures in patients with psychotic disorders and healthy controls.
Adult
Brain
/ metabolism
Case-Control Studies
Cerebral Cortex
/ metabolism
Complement C4
/ genetics
Female
Follow-Up Studies
Genetic Markers
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Immunologic Factors
/ genetics
Ireland
/ epidemiology
Male
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Prognosis
Psychotic Disorders
/ epidemiology
Risk Factors
C4
complement
genetics
hippocampus
psychosis
schizophrenia
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
01
08
2019
revised:
26
11
2019
accepted:
12
08
2020
pubmed:
13
9
2020
medline:
29
6
2021
entrez:
12
9
2020
Statut:
ppublish
Résumé
Multiple genome-wide association studies of schizophrenia have reported associations between genetic variants within the MHC region and disease risk, an association that has been partially accounted for by alleles of the complement component 4 (C4) gene. Following on previous findings of association between both C4 and other complement-related variants and memory function, we tested the hypothesis that polygenic scores calculated based on identified schizophrenia risk alleles within the "complement" system would be broadly associated with memory function and associated brain structure. We tested this using a polygenic risk score (PRS) calculated for complement genes, but excluding C4 variants. Higher complement-based PRS scores were observed to be associated with lower memory scores for the sample as a whole (N = 620, F change = 8.25; p = .004). A significant association between higher PRS and lower hippocampal volume was also observed (N = 216, R
Identifiants
pubmed: 32918526
doi: 10.1002/ajmg.b.32820
doi:
Substances chimiques
Complement C4
0
Genetic Markers
0
Immunologic Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
445-453Informations de copyright
© 2020 Wiley Periodicals LLC.
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