Being on the side of old findings: progesterone elevation on the day of oocyte maturation induction does not affect embryological parameters throughout the blastocyst culture period.
Blastocyst culture
Blastulation
Excellent-quality blastocyst formation rate
Progesterone elevation
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
16
03
2020
accepted:
05
09
2020
pubmed:
13
9
2020
medline:
16
3
2021
entrez:
12
9
2020
Statut:
ppublish
Résumé
To investigate whether there is any detrimental effect of progesterone elevation (PE) on the day of oocyte maturation induction on embryological development potentials. This retrospective single-center cohort study included a total of 1485 individual intracytoplasmic sperm injection (ICSI) cycles between January 2014 and December 2018. Serum progesterone (P) levels were measured on the day of oocyte maturation induction following the GnRH antagonist suppression protocol. Embryological parameters such as maturation, fertilization rate (FR), top-quality embryo (TQE) formation rate per 2PN on day 3, and excellent-quality blastocyst (EQB) formation rate per 2PN on day 5/6 were recorded. The inclusion criteria for women were an age ≤ 37 years, a BMI ≤ 30 kg/m Peak E2 level and total number of oocytes retrieved were significantly related to PE (p < 0.001). FR did not display a significance difference between groups (p = 0.108). The TQE and the blastulation rates were not affected by PE (p = 0.82 and p = 0.68, respectively). Chi square analysis revealed a significant relationship between PE and the EQB formation rate (p = 0.01). GEE analysis failed to present any statistical significance regarding the effect of PE on neither the TQE nor the EQB formation rates per 2PN [OR 1.07; 95% (0.98-1.16) p = 0.113 and OR 0.93; 95% (0.80-1.07) p = 0.32, respectively]. In accordance with previously published papers, our study could not find any detrimental effect of PE on embryological outcomes throughout the blastocyst culture period.
Identifiants
pubmed: 32918591
doi: 10.1007/s00404-020-05792-z
pii: 10.1007/s00404-020-05792-z
doi:
Substances chimiques
Hormone Antagonists
0
Progesterone
4G7DS2Q64Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
581-587Références
Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC (2013) Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update 19(5):433–457
doi: 10.1093/humupd/dmt014
Kolibianakis EM, Venetis CA, Bontis J, Tarlatzis BC (2012) Significantly lower pregnancy rates in the presence of progesterone elevation in patients treated with GnRH antagonists and gonadotrophins: a systematic review and meta-analysis. Curr Pharm Biotechnol 13(3):464–470
doi: 10.2174/138920112799361927
Griesinger G, Mannaerts B, Andersen CY, Witjes H, Kolibianakis EM, Gordon K (2013) Progesterone elevation does not compromise pregnancy rates in high responders: a pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in six trials. FertilSteril 100(6):1622–1628
Labarta E, Martínez-Conejero JA, Alamá P, Horcajadas JA, Pellicer A, Simón C, Bosch E (2011) Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 26(7):1813–1825
doi: 10.1093/humrep/der126
Van Vaerenbergh I, Fatemi HM, Blockeel C, Van Lommel L, In't Veld P, Schuit F, Kolibianakis EM, Devroey P, Bourgain C (2011) Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression. Reprod Biomed Online. 22(3):263–271
doi: 10.1016/j.rbmo.2010.11.002
Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Jenkins J, Pellicer A (2010) Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod 25(8):2092–2100
doi: 10.1093/humrep/deq125
Al-Azemi KD, Kolibianakis EM, Humaidan P, Van Vaerenbergh I, Devroey P, Fatemi HM (2012) Elevated progesterone during ovarian stimulation for IVF. Reprod Biomed Online 24(4):381–388
doi: 10.1016/j.rbmo.2012.01.010
Huang B, Ren X, Wu L, Zhu L, Xu B, Li Y, Ai J, Jin L (2016) Elevated progesterone levels on the day of oocyte maturation may affect top quality embryo IVF cycles. PLoS ONE 11(1):0145895
Vanni VS, Somigliana E, Reschini M, Pagliardini L, Marotta E, Faulisi S, Paffoni A, Vigano P, Vegetti W, Candiani M, Papaleo E (2017) Top quality blastocyst formation rates in relation to progesterone levels on the day of oocyte maturation in GnRH antagonist IVF/ICSI cycles. PLoS ONE 12:5
doi: 10.1371/journal.pone.0176482
Racca A, Santos-Ribeiro S, De Munck N, Mackens S, Drakopoulos P, Camus M, Verheyen G, Tournaye H, Blockeel C (2018) Impact of late-follicular phase elevated serum progesterone on cumulative live birth rates: is there a deleterious effect on embryo quality? Hum Reprod 33(5):860–868
doi: 10.1093/humrep/dey031
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S (2011) Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders. FertilSteril 96(2):516–518
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S (2011) Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. FertilSteril 96(2):344–348
Scholtes MC, Zeilmaker GH (1996) A prospective, randomized study of embryo transfer results after 3 or 5 days of embryo culture in in vitro fertilization. FertilSteril 65(6):1245–1248
Gardner DK, Schoolcraft WB (1999) Culture and transfer of human blastocysts. CurrOpinObstetGynecol 11(3):307–311
Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB (2000) Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. FertilSteril 73(6):1155–1158
Martinez F, Rodriguez I, Devesa M, Buxaderas R, Gomez MJ, Coroleu B (2016) Should progesterone on the human chorionic gonadotropin day still be measured? FertilSteril 105:86–92
Oktem O, Akin N, Bildik G, Yakin K, Alper E, Balaban B, Urman B (2017) FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization. Hum Reprod 32(3):643–652
doi: 10.1093/humrep/dex010
Kofinas JD, Mehr H, Ganguly N, Biley Y, Bochkovsky S, McCulloh D, Grifo J (2016) Is it the egg or the endometrium? Elevated progesterone on day of trigger is not associated with embryo ploidy nor decreased success rates in subsequent embryo transfer cycles. J Assist Reprod Genet 33(9):1169–1174. https://doi.org/10.1007/s10815-016-0752-y
doi: 10.1007/s10815-016-0752-y
pubmed: 27262838
pmcid: 5010810
Melo MAB, Meseguer M, Garrido N, Bosch E, Pellicer A, Remohí J (2006) The significance of premature luteinization in an oocyte-donation programme. Hum Reprod 21(6):1503–1507
doi: 10.1093/humrep/dei474
Check JH, Hourahi C, Choe JK, Callan C, Adelson HG (1994) Pregnancy rates in donors versus recipients according to the serum progesterone level at the time of human chorionic gonadotropin in a shared oocyte program. FertilSteril 61:262–264
Hofmann GE, Bentzien F, Bergh PA, Garrisi GJ, Williams MC, Guzman I, Navot D (1993) Premature luteinization in controlled ovarian hyperstimulation has no adverse effect on oocyte and embryo quality. FertilSteril 60(4):675–679
Legro RS, Ary BA, Paulson RJ, Stanczyk FZ, Sauer MV (1993) Premature luteinization as detected by elevated serum progesterone is associated with a higher pregnancy rate in donor oocyte in-vitro fertilization. Hum Reprod 8(9):1506–1511
doi: 10.1093/oxfordjournals.humrep.a138288
Fanchin R, Righini C, Olivennes F, de Ziegler D, Selva J, Frydman R (1996) Premature progesterone elevation does not alter oocyte quality in in vitro fertilisation. FertilSteril 65:1178–1183
McLernon DJ, Steyerberg EW, Te Velde ER, Lee AJ, Bhattacharya S (2016) Predicting the chances of a live birth after one or more complete cycles of in vitro fertilisation: population based study of linked cycle data from 113 873 women. BMJ 16:355–5735