Peptides Derived From Insulin Granule Proteins Are Targeted by CD8
Adult
Alternative Splicing
Animals
CD8-Positive T-Lymphocytes
Case-Control Studies
Chromogranins
/ genetics
Computer Simulation
Data Mining
Diabetes Mellitus, Type 1
/ genetics
Epitopes
Female
Gene Expression Regulation
HLA-A3 Antigen
Humans
Insulin
Male
Mice
Mice, Inbred NOD
Neuroendocrine Secretory Protein 7B2
/ genetics
Protein Binding
RNA, Messenger
/ genetics
Urocortins
/ genetics
Young Adult
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
05
01
2020
accepted:
31
08
2020
pubmed:
16
9
2020
medline:
27
1
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
The antigenic peptides processed by β-cells and presented through surface HLA class I molecules are poorly characterized. Each HLA variant (e.g., the most common being HLA-A2 and HLA-A3) carries some peptide-binding specificity. Hence, features that, despite these specificities, remain shared across variants may reveal factors favoring β-cell immunogenicity. Building on our previous description of the HLA-A2/A3 peptidome of β-cells, we analyzed the HLA-A3-restricted peptides targeted by circulating CD8
Identifiants
pubmed: 32928873
pii: db20-0013
doi: 10.2337/db20-0013
doi:
Substances chimiques
Chromogranins
0
Epitopes
0
HLA-A3 Antigen
0
Insulin
0
Neuroendocrine Secretory Protein 7B2
0
RNA, Messenger
0
Ucn3 protein, mouse
0
Urocortins
0
Banques de données
figshare
['10.2337/figshare.12899315']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2678-2690Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 by the American Diabetes Association.