Obstetric and perinatal outcomes in cases of congenital Zika syndrome.
Adult
Female
Follow-Up Studies
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Male
Perinatal Care
/ methods
Perinatal Mortality
Pregnancy
Pregnancy Complications, Infectious
/ diagnosis
Pregnancy Outcome
Prenatal Diagnosis
/ methods
Prognosis
Prospective Studies
Retrospective Studies
Syndrome
Zika Virus Infection
/ congenital
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
09
01
2020
revised:
02
09
2020
accepted:
10
09
2020
pubmed:
18
9
2020
medline:
26
10
2021
entrez:
17
9
2020
Statut:
ppublish
Résumé
To describe obstetric and perinatal outcomes in cases of congenital Zika syndrome (CZS). A dual prospective and retrospective cohort study involving 102 pairs of mothers and fetuses/children with CZS whose infection was confirmed by testing for the Zika virus in amniotic fluid, umbilical cord blood, and fragments from the placenta of the newborn infant (confirmed CZS), or by intrauterine imaging tests (neurosonography), and/or postnatal computed tomography (presumed CZS). Suspicion of CZS was investigated by ultrasonography during pregnancy in 52.9% of cases. The principal prenatal imaging findings were ventriculomegaly (43.1%) and microcephaly (42.2%). Median gestational age at delivery was 39 weeks, with 15.7% being premature. Mean head circumference at birth was 30.0 ± 2.3 cm, with 66% of cases being classified as having microcephaly. Arthrogryposis was found in 10 cases (9.8%). There were no fetal deaths; however, nine neonatal deaths were recorded, and three autopsies were performed. Neonatal mortality was high, almost 10%. Regarding the abnormalities of CZS, microcephaly, although common, was not present in all cases and intracranial findings need to be taken into consideration for diagnosis. Therefore, ultrasound screening during pregnancy should be systematized and expanded in endemic zones.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1732-1740Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
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