Tissue Doppler and speckle tracking echocardiography assessment of left ventricular function in children with cystic fibrosis.
Doppler tissue imaging
cystic fibrosis
strain echocardiography
ventricular dysfunction
Journal
Echocardiography (Mount Kisco, N.Y.)
ISSN: 1540-8175
Titre abrégé: Echocardiography
Pays: United States
ID NLM: 8511187
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
05
05
2020
revised:
21
08
2020
accepted:
25
08
2020
pubmed:
20
9
2020
medline:
24
6
2021
entrez:
19
9
2020
Statut:
ppublish
Résumé
Cystic fibrosis may lead to left ventricular (LV) dysfunction. This dysfunction can be documented by methods such as tissue Doppler echocardiographic (TDI) imaging and two-dimensional speckle tracking echocardiography (STE) in early stage. This was prospective cohort study. A total of 34 patients diagnosed with cystic fibrosis (mean age and SD 9.9 ± 4.9 years) and 37 healthy control subjects with a comparable gender and age distribution (mean age 9.8 ± 4.3) were studied. The results for the two groups were compared along with the results of published reports. No significant relationship was found between the groups in terms of systolic and diastolic measurements of the interventricular septum and posterior left ventricular wall, and ejection fraction (P > .05). Myocardial performance indexes of left ventricular free wall and interventricular septum increased in the patient group compared with the controls (P < .05). As measured by STE, seven segments in the LV myocardial longitudinal strain and three segments in the LV myocardial circumferential strain showed significant reductions in patients with cystic fibrosis compared with controls (P < .05). The longitudinal global, circumferential global, and total global strain values had no significant difference between the groups (P > .05). Longitudinal strain rates and circumferential strain rates were both lower in five segments in the patient group (P < .05). Tissue Doppler echocardiographic imaging and STE may help identifying subclinical LV dysfunction in cystic fibrosis patients with unremarkable conventional echocardiography. They may be considered for the routine follow-up of cystic fibrosis patients.
Sections du résumé
BACKGROUND
Cystic fibrosis may lead to left ventricular (LV) dysfunction. This dysfunction can be documented by methods such as tissue Doppler echocardiographic (TDI) imaging and two-dimensional speckle tracking echocardiography (STE) in early stage.
STUDY DESIGN
This was prospective cohort study.
METHODS
A total of 34 patients diagnosed with cystic fibrosis (mean age and SD 9.9 ± 4.9 years) and 37 healthy control subjects with a comparable gender and age distribution (mean age 9.8 ± 4.3) were studied. The results for the two groups were compared along with the results of published reports.
RESULTS
No significant relationship was found between the groups in terms of systolic and diastolic measurements of the interventricular septum and posterior left ventricular wall, and ejection fraction (P > .05). Myocardial performance indexes of left ventricular free wall and interventricular septum increased in the patient group compared with the controls (P < .05). As measured by STE, seven segments in the LV myocardial longitudinal strain and three segments in the LV myocardial circumferential strain showed significant reductions in patients with cystic fibrosis compared with controls (P < .05). The longitudinal global, circumferential global, and total global strain values had no significant difference between the groups (P > .05). Longitudinal strain rates and circumferential strain rates were both lower in five segments in the patient group (P < .05).
CONCLUSIONS
Tissue Doppler echocardiographic imaging and STE may help identifying subclinical LV dysfunction in cystic fibrosis patients with unremarkable conventional echocardiography. They may be considered for the routine follow-up of cystic fibrosis patients.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1634-1641Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Bright-Thomas RJ, Ray SG, Webb AK. Pulmonary artery pressure in cystic fibrosis adults: characteristics, clinical correlates and long-term follow-up. J Cyst Fibros. 2012;11(6):532-538.
Brıght-Tomas RJ, Webb AK. The heart in cystic fibrosis. J R Soc Med. 2002;95(41):2-10.
Tonelli AR, Fernandez-Bussy S, Lodhi S, et al. Prevalence of pulmonary hypertension in end-stage cystic fibrosis and correlation with survival. J Heart Lung Transplant. 2010;29(8):865-872.
Bano-Rodrigo A, Salcedo-Posadas A, Villa-Asensi JR, et al. Right ventricular dysfunction in adolescents with mild cystic fibrosis. J Cyst Fibros. 2012;11(4):274-280.
Labombarda F, Pellissier A, Ellafi M, et al. Myocardial strain assessment in cystic fibrosis. J Am Soc Echocardiogr. 2011;24(9):1037-1045.
Koelling TM, Dec GW, Ginns LC, Semigran MJ. Left ventricular diastolic function in patients with advanced cystic fibrosis. Chest. 2003;123:1488-1494.
Rovedder PME, Ziegler B, Pinotti AFF, et al. Prevalence of pulmonary hypertension evaluated by Doppler echocardiography in a population of adolescent and adult patients with cystic fibrosis. J. Bras Pneumol. 2008;34(2):83-90.
Ozcelik N, Shell R, Holtzlander M, et al. Decreased right ventricular function in healthy pediatric cystic fibrosis patients versus non-cystic fibrosis patients. Pediatr Cardiol. 2013;34(1):159-164.
Sellers ZM, Kovacs A, Weinheimer CJ, et al. Left ventricular and aortic dysfunction in cystic fibrosis mice. J Cyst Fibros. 2013;12(5):517-524.
Sellers ZM, McGlocklin L, Brasch A. Strain rate echocardiography uncovers subclinical left ventricular dysfunction in cystic fibrosis. J Cyst Fibros. 2015;14(5):654-660.
Ionescu AA, Ionescu AA, Payne N, Obieta-fresnedo I, Fraser AG, Shale DJ. Subclinical right ventricular dysfunction in cystic fibrosis. Am J Respir Crit Care Med. 2001;163(5):1212-1218.
Matsui H, Satomi G, Yasukochi S, Kaneko S, Haseyama K. Evaluation of right ventricular contraction by myocardial strain in children using a two-dimensional tissue tracking method. Pediatr Cardiol. 2008;29:377-381.
Lopez-Candales A, Rajagopalan N, Gulyasy B, Edelman K, Bazaz R. Differential strain and velocity generation along the right ventricular free wall in pulmonary hypertension. Can J Cardiol. 2009;25:73-77.
Simon MA, Rajagopalan N, Mathier MA, Shroff SG, Pinsky MR, López-Candales A. Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension. Congest Heart Fail. 2009;15:271-276.
Takigiku K, Takeuchi M, Izumi C, et al. Normal range of left ventricular 2-dimensional strain. Circ J. 2012;76(11):2623-2632.
Dandel M, Lehmkuhl H, Knosalla C, et al. Strain and strain rate imaging by echocardiography - Basic concepts and clinical applicability. Curr Cardiol Rev. 2009;5(2):133-148.
Geyer H, Caracciolo G, Abe H, et al. Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J Am Soc Echocardiogr. 2010;23(4):351-369.
Gonzales MP, Suarez L, Camarero C, et al. Myocardial fibrosis in 2 children with cystic fibrosis. An Esp Pediatr. 1987;27:382-384.
Wiebicke W, Artlich A, Gerling I. Myocardial fibrosis: a rare complication in patients with cystic fibrosis. Eur J Pediatr. 1993;152:694-696.
Bismuth E, Laborde K, Taupin P, et al. Glucose tolerance and insulin secretion, morbidity, and death in patients with cystic fibrosis. J Pediatr. 2008;152:540-545.
Fang ZY, Prins JB, Marwick TH. Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr Rev. 2004;25:543-567.
Kuzumoto M, Takeuchi A, Nakai H, et al. Simulation analysis of intracellular Na+ and Cl− homeostasis during beta 1-adrenergic stimulation of cardiac myocyte. Prog Biophys Mol Biol. 2008;96:171-186.
Santos M, Shah AM. Alterations in cardiac structure and function in hypertension. Curr Hypertens Rep. 2014;16:428.
Burton JO, Kosheed S, McIntyre CW. Haemodialysis induced acute cardiac injury is associated with increased rates of ventricular arrhythmias. Ren Fail. 2008;30:1-9.
Hothi DK, Rees L, Marek J, Burton J, McIntyre CW. Pediatric myocardial stunning underscores the cardiac toxicity of conventional hemodialysis treatments. Clin J Am Soc Nephrol. 2009;4:790-797.
Eising JB, Ent CK, Teske AJ, Vanderschuren MM, Uiterwaal C, Meijboom JF. Young patients with cystic fibrosis demonstrate subtle alterations of the cardiovascular system. J Cyst Fibros. 2018;17:643-649.
Rakha S, Aboelenin HM. Left ventricular functions in pediatric patients with ten years or more type 1 diabetes mellitus: conventional echocardiography, tissue Doppler, and two-dimensional speckle tracking study. Pediatr Diabetes. 2019;20(7):946-954.
Fontana A, Zambon A, Cesana F, Giannattasio C, Trocino G. Tissue Doppler, triplane echocardiography, and speckle tracking echocardiography: different ways of measuring longitudinal myocardial velocity and deformation parameters. A comparative clinical study. Echocardiography. 2012;29(4):428-437.