Emerging insights into symmetry breaking in centriole duplication: updated view on centriole duplication theory.

Cell Cycle Cell Cycle Proteins Centrioles Protein Serine-Threonine Kinases / genetics

Journal

Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784

Informations de publication

Date de publication:
02 2021
Historique:
received: 26 07 2020
revised: 22 08 2020
accepted: 25 08 2020
pubmed: 22 9 2020
medline: 16 10 2021
entrez: 21 9 2020
Statut: ppublish

Résumé

Centriole duplication occurs once per cell cycle. Since only a single daughter centriole is assembled adjacent to each mother centriole, symmetry around the mother centriole must be broken in the process of centriole duplication. Recent studies have established that Plk4, a master kinase for centriole duplication, can self-assemble into condensates, and have suggested that this Plk4 self-assembly is the key to symmetry breaking. Here, we present the current hypotheses for how Plk4 could break symmetry around the mother centriole via autonomous regulation. After this initial symmetry-breaking process, the ring-to-dot conversion of Plk4 around the mother centriole completes the selection of the site for procentriole formation. We also discuss how this dynamic transition contributes to the strict regulation of centriole duplication.

Identifiants

DOI: 10.1016/j.sbi.2020.08.005 PMID: 32956908
pubmed: 32956908
pii: S0959-440X(20)30140-8
doi: 10.1016/j.sbi.2020.08.005
pii:
doi:

Substances chimiques

Cell Cycle Proteins 0
Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

8-14

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Shohei Yamamoto (S)

Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Tokyo 113-0033, Japan.

Daiju Kitagawa (D)

Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Tokyo 113-0033, Japan. Electronic address: dkitagawa@mol.f.u-tokyo.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Emerging insights into symmetry breaking in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Emerging insights into symmetry breaking in...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Appareil du fuseau › Pôles du fuseau › Centrosome › Centrioles › Emerging insights into symmetry breaking in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Emerging insights into symmetry breaking in...