GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of G
Acromegaly
/ metabolism
Animals
Body Composition
Cell Line
GTP-Binding Protein alpha Subunits, Gq-G11
/ genetics
GTP-Binding Protein alpha Subunits, Gs
/ genetics
Gigantism
/ metabolism
Growth Hormone
/ metabolism
Growth Hormone-Secreting Pituitary Adenoma
/ genetics
HEK293 Cells
Humans
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Pituitary Gland
/ metabolism
Protein Kinase C
/ metabolism
Rats
Receptors, G-Protein-Coupled
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 09 2020
21 09 2020
Historique:
received:
18
10
2019
accepted:
25
08
2020
entrez:
22
9
2020
pubmed:
23
9
2020
medline:
9
10
2020
Statut:
epublish
Résumé
Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH-secreting pituitary tumors over-expressing the orphan G-protein coupled receptor, GPR101. The role of GPR101 in GH secretion remains obscure. We studied GPR101 signaling pathways and their effects in HEK293 and rat pituitary GH3 cell lines, human tumors and in transgenic mice with elevated somatotrope Gpr101 expression driven by the rat Ghrhr promoter (Ghrhr
Identifiants
pubmed: 32958754
doi: 10.1038/s41467-020-18500-x
pii: 10.1038/s41467-020-18500-x
pmc: PMC7506554
doi:
Substances chimiques
GPR101 protein, human
0
Receptors, G-Protein-Coupled
0
Growth Hormone
9002-72-6
Protein Kinase C
EC 2.7.11.13
GTP-Binding Protein alpha Subunits, Gq-G11
EC 3.6.5.1
GTP-Binding Protein alpha Subunits, Gs
EC 3.6.5.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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