CRISPR-based gene expression control for synthetic gene circuits.
Animals
Binding Sites
CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Editing
Gene Expression
Gene Expression Profiling
Gene Expression Regulation
Gene Regulatory Networks
Genes, Synthetic
Genetic Engineering
Humans
Mice
Synthetic Biology
Transcription Factors
/ metabolism
CRISPR
gene expression and regulation
synthetic biological circuits
synthetic biology
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
30 10 2020
30 10 2020
Historique:
received:
03
07
2020
revised:
27
08
2020
accepted:
28
08
2020
pubmed:
24
9
2020
medline:
10
8
2021
entrez:
23
9
2020
Statut:
ppublish
Résumé
Synthetic gene circuits allow us to govern cell behavior in a programmable manner, which is central to almost any application aiming to harness engineered living cells for user-defined tasks. Transcription factors (TFs) constitute the 'classic' tool for synthetic circuit construction but some of their inherent constraints, such as insufficient modularity, orthogonality and programmability, limit progress in such forward-engineering endeavors. Here we review how CRISPR (clustered regularly interspaced short palindromic repeats) technology offers new and powerful possibilities for synthetic circuit design. CRISPR systems offer superior characteristics over TFs in many aspects relevant to a modular, predictable and standardized circuit design. Thus, the choice of CRISPR technology as a framework for synthetic circuit design constitutes a valid alternative to complement or replace TFs in synthetic circuits and promises the realization of more ambitious designs.
Identifiants
pubmed: 32964920
pii: 226494
doi: 10.1042/BST20200020
pmc: PMC7609024
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1979-1993Informations de copyright
© 2020 The Author(s).
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