Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis.

Adipogenesis / genetics Adipose Tissue / metabolism Delta-5 Fatty Acid Desaturase Female Gene Expression Regulation Genotype Humans Male Oxidative Phosphorylation Sex Characteristics Transcription Factors / metabolism

Journal

Genome research
ISSN: 1549-5469
Titre abrégé: Genome Res
Pays: United States
ID NLM: 9518021

Informations de publication

Date de publication:
10 2020
Historique:
received: 10 04 2020
accepted: 27 08 2020
pubmed: 25 9 2020
medline: 17 11 2021
entrez: 24 9 2020
Statut: ppublish

Résumé

Sex differences in adipose tissue distribution and function are associated with sex differences in cardiometabolic disease. While many studies have revealed sex differences in adipocyte cell signaling and physiology, there is a relative dearth of information regarding sex differences in transcript abundance and regulation. We investigated sex differences in subcutaneous adipose tissue transcriptional regulation using omic-scale data from ∼3000 geographically and ethnically diverse human samples. We identified 162 genes with robust sex differences in expression. Differentially expressed genes were implicated in oxidative phosphorylation and adipogenesis. We further determined that sex differences in gene expression levels could be related to sex differences in the genetics of gene expression regulation. Our analyses revealed sex-specific genetic associations, and this finding was replicated in a study of 98 inbred mouse strains. The genes under genetic regulation in human and mouse were enriched for oxidative phosphorylation and adipogenesis. Enrichment analysis showed that the associated genetic loci resided within binding motifs for adipogenic transcription factors (e.g., PPARG and EGR1). We demonstrated that sex differences in gene expression could be influenced by sex differences in genetic regulation for six genes (e.g.,

Identifiants

DOI: 10.1101/gr.264614.120 PMID: 32967914 PMC: PMC7605264
pubmed: 32967914
pii: gr.264614.120
doi: 10.1101/gr.264614.120
pmc: PMC7605264
doi:

Substances chimiques

Delta-5 Fatty Acid Desaturase 0
Transcription Factors 0
FADS1 protein, human EC 1.14.19.3

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1379-1392

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007646
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK090111
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118287
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007284
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118243
Pays : United States

Informations de copyright

© 2020 Anderson et al.; Published by Cold Spring Harbor Laboratory Press.

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Auteurs

Warren D Anderson (WD)

Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA.
ORCID: 0000-0002-7235-5869

Joon Yuhl Soh (JY)

Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA.

Sarah E Innis (SE)

Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, USA.

Alexis Dimanche (A)

Physics Department, Southwestern University, Georgetown, Texas 78626, USA.

Lijiang Ma (L)

Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Carl D Langefeld (CD)

Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, USA.

Mary E Comeau (ME)

Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, USA.

Swapan K Das (SK)

Department of Internal Medicine, Section of Endocrinology and Metabolism, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, USA.

Eric E Schadt (EE)

Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Johan L M Björkegren (JLM)

Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Mete Civelek (M)

Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA.
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Adipogenèse › Sex differences in human adipose tissue gene...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Sex differences in human adipose tissue gene...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Fatty acid desaturases › Delta-5 fatty acid desaturase › Sex differences in human adipose tissue gene...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Sex differences in human adipose tissue gene...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Sex differences in human adipose tissue gene...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex differences in human adipose tissue gene...
questionsmedicales.fr › Métabolisme › Phosphorylation › Phosphorylation oxydative › Sex differences in human adipose tissue gene...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Sex differences in human adipose tissue gene...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Sex differences in human adipose tissue gene...