Solanine Attenuates Hepatocarcinoma Migration and Invasion Induced by Acetylcholine.

Acetylcholine / pharmacology Carcinoma, Hepatocellular / drug therapy Cell Line, Tumor Cell Movement Cell Proliferation Epithelial-Mesenchymal Transition Humans Liver Neoplasms / drug therapy Solanine / pharmacology Tumor Microenvironment
acetylcholine exosome hepatocarcinoma migration solanine

Journal

Integrative cancer therapies
ISSN: 1552-695X
Titre abrégé: Integr Cancer Ther
Pays: United States
ID NLM: 101128834

Informations de publication

Date de publication:
Historique:
entrez: 25 9 2020
pubmed: 26 9 2020
medline: 19 8 2021
Statut: ppublish

Résumé

Evidence has provided an explanation of the correlation between the nervous system and the tumor microenvironment. Neurotransmitters may be involved in different aspects of cancer progression. The glycoalkaloid solanine has been reported to suppress neural signaling pathways and exists in numerous plants, including We evaluated the potentials of solanine on inhibiting acetylcholine-induced cell proliferation and migration in hepatocellular carcinoma cells. The results indicated that solanine markedly attenuated cell proliferation and migration via inhibiting epithelial-mesenchymal transition and matrix metalloproteinases in acetylcholine-treated Hep G2 cells. In addition, exosomes derived from acetylcholine-treated Hep G2 cells were isolated, and solanine showed inhibiting effects of extrahepatic metastasis on blocking cell proliferation in exosome-treated A549 lung carcinoma cells through regulating microRNA-21 expression. Solanine has strong potential for application in integrative cancer therapy.

Identifiants

DOI: 10.1177/1534735420909895 PMID: 32975458 PMC: PMC7522814
pubmed: 32975458
doi: 10.1177/1534735420909895
pmc: PMC7522814
doi:

Substances chimiques

Solanine 20562-02-1
Acetylcholine N9YNS0M02X

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1534735420909895

Commentaires et corrections

Type : ErratumIn

Références

Theor Appl Genet. 2016 Dec;129(12):2281-2294
pubmed: 27744490
Mol Med Rep. 2015 Oct;12(4):4917-24
pubmed: 26151427
Pharmacol Ther. 2019 Feb;194:222-254
pubmed: 30291908
Trends Pharmacol Sci. 2008 Mar;29(3):151-8
pubmed: 18262664
RNA. 2008 Nov;14(11):2348-60
pubmed: 18812439
Evid Based Complement Alternat Med. 2015;2015:675270
pubmed: 26221175
Hepatol Int. 2008 Jun;2(2):237-43
pubmed: 19669310
Thorac Cancer. 2017 Sep;8(5):461-470
pubmed: 28660665
J Mol Neurosci. 2014 Jul;53(3):335-44
pubmed: 24158730
Signal Transduct Target Ther. 2017 Jan 06;2:16036
pubmed: 29263908
Int Immunopharmacol. 2015 Nov;29(1):36-44
pubmed: 26071223
Clin Exp Metastasis. 1995 Mar;13(2):67-88
pubmed: 7882617
Clin Exp Metastasis. 2004;21(4):285-92
pubmed: 15554384
Nature. 2007 Oct 11;449(7163):682-8
pubmed: 17898713
Int J Biochem Cell Biol. 2009 Jul;41(7):1441-51
pubmed: 19401144
Evid Based Complement Alternat Med. 2012;2012:859185
pubmed: 23304219
Oncotarget. 2016 Jul 12;7(28):44630-44643
pubmed: 27329839
Cancer Res. 2003 Dec 1;63(23):8090-6
pubmed: 14678958
Trends Neurosci. 2016 Dec;39(12):880-889
pubmed: 27832915
Prog Neurobiol. 2010 Oct;92(2):212-26
pubmed: 20685379
Biomed Res Int. 2014;2014:805926
pubmed: 24949471
J Chem Ecol. 1987 Oct;13(10):2009-22
pubmed: 24301471
J Natl Cancer Inst. 2010 Aug 4;102(15):1199-205
pubmed: 20554942
Integr Cancer Ther. 2015 Nov;14(6):546-55
pubmed: 26069278
J Sci Food Agric. 2010 Dec;90(15):2709-15
pubmed: 20812379
J Clin Oncol. 2011 Jul 1;29(19):2635-44
pubmed: 21632503
Evid Based Complement Alternat Med. 2013;2013:514719
pubmed: 23843876
Nature. 2015 Nov 19;527(7578):329-35
pubmed: 26524530
Molecules. 2016 Jun 03;21(6):
pubmed: 27271583
Oncogene. 2001 Dec 6;20(56):8066-74
pubmed: 11781819
Biomed Rep. 2016 May;4(5):515-518
pubmed: 27123240
Biol Pharm Bull. 2010;33(10):1685-91
pubmed: 20930376
Molecules. 2016 Apr 28;21(5):
pubmed: 27136519
Nat Cell Biol. 2010 Mar;12(3):247-56
pubmed: 20173740
Nat Rev Cancer. 2002 Jun;2(6):442-54
pubmed: 12189386
Cancer Res. 2015 May 1;75(9):1777-81
pubmed: 25795709
J Cell Biol. 2006 Mar 27;172(7):973-81
pubmed: 16567498
J Agric Food Chem. 2015 Apr 8;63(13):3323-37
pubmed: 25821990
PLoS One. 2014 Feb 05;9(2):e87868
pubmed: 24505326
J Ethnopharmacol. 2008 Jan 17;115(2):194-202
pubmed: 18022776
Biol Pharm Bull. 2015;38(9):1410-4
pubmed: 26328498
Cell Death Discov. 2016 Oct 17;2:16063
pubmed: 27785369

Auteurs

Liang-Tzung Lin (LT)

Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Chen-Yen Choong (CY)

Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medicine University Hospital, Taipei 11042, Taiwan.

Chen-Jei Tai (CJ)

Department of Traditional Chinese Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
ORCID: 0000-0001-7304-6489

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Solanine › Solanine Attenuates Hepatocarcinoma Migration...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Solanine Attenuates Hepatocarcinoma Migration...