α
Acetylation
Amino Acid Sequence
Chromatography, High Pressure Liquid
Esters
/ chemistry
Histidine
/ chemistry
Humans
Hydrogen-Ion Concentration
Hydroxides
/ chemistry
Mutagenesis, Site-Directed
Peptides
/ analysis
Protease Inhibitors
/ chemistry
Recombinant Proteins
/ biosynthesis
Sequence Alignment
Sulfhydryl Compounds
/ chemistry
Tandem Mass Spectrometry
Thermolysin
/ antagonists & inhibitors
alpha-Macroglobulins
/ chemistry
A2ML1
alpha 2 macroglobulin like protein 1
alpha-2-macroglobulin
complement
inhibition mechanism
mutagenesis
mutagenesis in vitro
protease
protease inhibitor
protein crosslinking
thiol ester
α2-macroglobulin
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
04 12 2020
04 12 2020
Historique:
received:
18
08
2020
revised:
18
09
2020
pubmed:
27
9
2020
medline:
5
5
2021
entrez:
26
9
2020
Statut:
ppublish
Résumé
Proteins in the α-macroglobulin (αM) superfamily use thiol esters to form covalent conjugation products upon their proteolytic activation. αM protease inhibitors use theirs to conjugate proteases and preferentially react with primary amines (
Identifiants
pubmed: 32978260
pii: S0021-9258(17)50488-3
doi: 10.1074/jbc.RA120.015694
pmc: PMC7864068
pii:
doi:
Substances chimiques
A2ML1 protein, human
0
Esters
0
Hydroxides
0
Peptides
0
Protease Inhibitors
0
Recombinant Proteins
0
Sulfhydryl Compounds
0
alpha-Macroglobulins
0
Histidine
4QD397987E
hydroxide ion
9159UV381P
Thermolysin
EC 3.4.24.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16732-16742Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 Harwood et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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