Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders.

Firmicutes/Bacteroidetes Apparent digestibility coefficients feces gut microflora longevity metabolic syndrome sarcopenic obesity stool testosterone type 2 diabetes mellitus (T2DM)

Journal

Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343

Informations de publication

Date de publication:
09 11 2020
Historique:
entrez: 29 9 2020
pubmed: 30 9 2020
medline: 21 9 2021
Statut: ppublish

Résumé

Androgen action generates sex-related differences that include changes in the gut microbiota composition. Hypoandrogenism and hyperandrogenism in males and females, respectively, are associated with the prevalence of metabolic disorders. Our recent work showed that male androgen receptor knockout (ARKO) mice developed high-fat diet (HFD)-dependent sarcopenic abdominal obesity, hyperglycemia, and hepatic steatosis, leading to early death. The ARKO mice also exhibited alterations in intestinal microbiota but did not experience metabolic abnormalities when administered with antibiotics. Here, we show that time-dependent changes in feed efficiency (ratio of body weight gain to food intake) and weight of dried feces-to-food ratio could be good markers for changes in gut microbiota.

Identifiants

pubmed: 32991827
doi: 10.1080/19490976.2020.1817719
pmc: PMC7781658
doi:

Substances chimiques

Androgens 0
Receptors, Androgen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1817719

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Auteurs

Naoki Harada (N)

Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University , Osaka, Japan.

Yukari Minami (Y)

Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University , Osaka, Japan.

Kazuki Hanada (K)

Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University , Osaka, Japan.

Ryo Hanaoka (R)

Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University , Osaka, Japan.

Yasuyuki Kobayashi (Y)

Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University , Osaka, Japan.

Takeshi Izawa (T)

Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University , Osaka, Japan.

Takashi Sato (T)

Institute for Molecular and Cellular Regulation, Gunma University , Maebashi, Japan.

Shigeaki Kato (S)

Graduate School of Science and Engineering, Iryo Sosei University , Fukushima, Japan.

Hiroshi Inui (H)

Division of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University , Osaka, Japan.

Ryoichi Yamaji (R)

Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University , Osaka, Japan.

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