First report of t(5;11) KMT2A-MAML1 fusion in de novo infant acute lymphoblastic leukemia.
Chromosomes, Human, Pair 11
/ genetics
Chromosomes, Human, Pair 5
/ genetics
DNA-Binding Proteins
/ genetics
Histone-Lysine N-Methyltransferase
/ genetics
Humans
Infant
Male
Myeloid-Lymphoid Leukemia Protein
/ genetics
Oncogene Proteins, Fusion
/ genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/ genetics
Prognosis
Transcription Factors
/ genetics
Translocation, Genetic
Acute leukemia
Infant leukemia
KMT2A-MAML1, Hematologic malignancies
Journal
Cancer genetics
ISSN: 2210-7762
Titre abrégé: Cancer Genet
Pays: United States
ID NLM: 101539150
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
03
04
2020
revised:
16
09
2020
accepted:
20
09
2020
pubmed:
30
9
2020
medline:
1
1
2021
entrez:
29
9
2020
Statut:
ppublish
Résumé
Infant acute lymphoblastic leukemia (ALL) comprises 2.5%-5% of pediatric ALL with inferior survival compared to older children. A majority of infants (80%) with ALL harbor KMT2A gene rearrangement, which portends a poor prognosis. Approximately 94 different partner genes have been identified to date. The common rearrangements include t(4;11)(q21;q23)KMT2A-AFF1,t(11;19) (q23;p13.3)KMT2A-MLLT1 and t(9;11)(p22;q23)KMT2A-MLLT3. We report a novel translocation t(5;11)(q35;q23)KMT2A-MAML1 in newly diagnosed infant precursor B-ALL. Long-term follow-up and a larger number of patients are needed to better understand its prognostic significance.
Identifiants
pubmed: 32992102
pii: S2210-7762(20)30273-8
doi: 10.1016/j.cancergen.2020.09.004
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
KMT2A protein, human
0
MAML1 protein, human
0
Oncogene Proteins, Fusion
0
Transcription Factors
0
Myeloid-Lymphoid Leukemia Protein
149025-06-9
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
31-33Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.