Application of a plasmin generation assay to define pharmacodynamic effects of tranexamic acid in women undergoing cesarean delivery.
fibrin
fibrinolysis
plasmin
pregnancy
tranexamic acid
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
04
07
2020
revised:
17
09
2020
accepted:
18
09
2020
pubmed:
2
10
2020
medline:
15
5
2021
entrez:
1
10
2020
Statut:
ppublish
Résumé
Essentials Tranexamic acid (TXA) is an antifibrinolytic drug used to reduce bleeding. Assaying plasmin generation (PG) in plasma detects clinically relevant TXA levels in vitro and ex vivo. 3.1-16.2 µg/mL TXA half-maximally inhibits PG in plasma from women undergoing cesarean delivery. PG velocity shows the strongest dose-relationship at low TXA concentrations (≤10 µg/mL). ABSTRACT: Background Tranexamic acid (TXA) is used to reduce bleeding. TXA inhibits plasmin(ogen) binding to fibrin and reduces fibrinolysis. TXA antifibrinolytic activity is typically measured by clot lysis assays; however, effects on plasmin generation (PG) are unclear due to a lack of tools to measure PG in plasma. Aims Develop an assay to measure PG kinetics in human plasma. Determine effects of TXA on PG and compare with fibrinolysis measured by rotational thromboelastometry (ROTEM). Methods We characterized effects of plasminogen, tissue plasminogen activator, fibrinogen, and α
Identifiants
pubmed: 33001565
doi: 10.1111/jth.15114
pmc: PMC7875467
mid: NIHMS1665074
pii: S1538-7836(22)00427-5
doi:
Substances chimiques
Antifibrinolytic Agents
0
Tranexamic Acid
6T84R30KC1
Tissue Plasminogen Activator
EC 3.4.21.68
Fibrinolysin
EC 3.4.21.7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-232Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL141640
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001877
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126974
Pays : United States
Organisme : NHLBI NIH HHS
ID : R33 HL141791
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001876
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL143403
Pays : United States
Informations de copyright
© 2020 International Society on Thrombosis and Haemostasis.
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