Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae.
Argentina
/ epidemiology
Cholera
/ epidemiology
DNA, Bacterial
/ genetics
Endemic Diseases
/ prevention & control
Genome, Bacterial
/ genetics
History, 19th Century
History, 20th Century
Humans
Molecular Sequence Annotation
Pandemics
/ history
Phylogeny
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Vibrio cholerae
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
02
04
2020
accepted:
03
09
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
21
10
2020
Statut:
epublish
Résumé
In order to control and eradicate epidemic cholera, we need to understand how epidemics begin, how they spread, and how they decline and eventually end. This requires extensive sampling of epidemic disease over time, alongside the background of endemic disease that may exist concurrently with the epidemic. The unique circumstances surrounding the Argentinian cholera epidemic of 1992-1998 presented an opportunity to do this. Here, we use 490 Argentinian V. cholerae genome sequences to characterise the variation within, and between, epidemic and endemic V. cholerae. We show that, during the 1992-1998 cholera epidemic, the invariant epidemic clone co-existed alongside highly diverse members of the Vibrio cholerae species in Argentina, and we contrast the clonality of epidemic V. cholerae with the background diversity of local endemic bacteria. Our findings refine and add nuance to our genomic definitions of epidemic and endemic cholera, and are of direct relevance to controlling current and future cholera epidemics.
Identifiants
pubmed: 33004800
doi: 10.1038/s41467-020-18647-7
pii: 10.1038/s41467-020-18647-7
pmc: PMC7530988
doi:
Substances chimiques
DNA, Bacterial
0
Banques de données
figshare
['10.6084/m9.figshare.11310131']
Types de publication
Comparative Study
Historical Article
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4918Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : KL2 TR001448
Pays : United States
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