Intensified Downstream Processing of Monoclonal Antibodies Using Membrane Technology.
downstream processing
membranes
monoclonal antibody
process integration
process intensification
Journal
Biotechnology journal
ISSN: 1860-7314
Titre abrégé: Biotechnol J
Pays: Germany
ID NLM: 101265833
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
pubmed:
3
10
2020
medline:
28
4
2021
entrez:
2
10
2020
Statut:
ppublish
Résumé
The need to intensify downstream processing of monoclonal antibodies to complement the advances in upstream productivity has led to increased attention toward implementing membrane technologies. With the industry moving toward continuous operations and single use processes, membrane technologies show promise in fulfilling the industry needs due to their operational flexibility and ease of implementation. Recently, the applicability of membrane-based unit operations in integrating the downstream process has been explored. In this article, the major developments in the application of membrane-based technologies in the bioprocessing of monoclonal antibodies are reviewed. The recent progress toward developing intensified end-to-end bioprocesses and the critical role membrane technology will play in achieving this goal are focused upon.
Identifiants
pubmed: 33006254
doi: 10.1002/biot.202000309
doi:
Substances chimiques
Antibodies, Monoclonal
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000309Subventions
Organisme : Australian Research Council Industrial Transformation Training Centre Program
ID : IC160100027
Organisme : Australian Research Council
ID : IC160100027
Informations de copyright
© 2020 The Authors. Biotechnology Journal published by Wiley-VCH GmbH.
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