miRNA signature in glioblastoma: Potential biomarkers and therapeutic targets.
Biomarker
Glioblastoma
miRNA
Journal
Experimental and molecular pathology
ISSN: 1096-0945
Titre abrégé: Exp Mol Pathol
Pays: Netherlands
ID NLM: 0370711
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
23
08
2020
revised:
19
09
2020
accepted:
28
09
2020
pubmed:
4
10
2020
medline:
3
2
2021
entrez:
3
10
2020
Statut:
ppublish
Résumé
MicroRNAs (miRNAs) are transcripts with sizes of about 22 nucleotides, which are produced through a multistep process in the nucleus and cytoplasm. These transcripts modulate the expression of their target genes through binding with certain target regions, particularly 3' suntranslated regions. They are involved in the pathogenesis of several kinds of cancers, such as glioblastoma. Several miRNAs, including miR-10b, miR-21, miR-17-92-cluster, and miR-93, have been up-regulated in glioblastoma cell lines and clinical samples. On the other hand, expression of miR-7, miR-29b, miR-32, miR-34, miR-181 family members, and a number of other miRNAs have been decreased in this type of cancer. In the current review, we explain the role of miRNAs in the pathogenesis of glioblastoma through providing a summary of studies that reported dysregulation of these epigenetic effectors in this kind of brain cancer.
Identifiants
pubmed: 33010295
pii: S0014-4800(20)30826-1
doi: 10.1016/j.yexmp.2020.104550
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104550Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.