Food dyes as P-glycoprotein modulators.
Drug transporter
Food dye
P-glycoprotein
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
08
07
2020
revised:
25
09
2020
accepted:
28
09
2020
pubmed:
5
10
2020
medline:
8
6
2021
entrez:
4
10
2020
Statut:
ppublish
Résumé
The drug transporter P-glycoprotein (P-gp) is often investigated in drug-interaction studies because the activity is modulated by a wide variety of xenobiotics including drugs, herbal products, and food components. In this study, we tested six common arylsulfonate food dyes-allura red, carmoisine, ponceau 4R, quinolone yellow, sunset yellow, and tartrazine-as activators and inhibitors of P-gp activity in vitro. The dyes were studied as P-gp activators by measuring ATPase activity in P-gp-expressing membranes. Compared to verapamil, a known activator of P-gp, the six food dyes showed no stimulatory activity. The potential for these six food dyes to act as P-gp inhibitors was tested in an intracellular efflux assay with P-gp-expressing cells. Compared to GF120918, a known P-gp inhibitor, there was no inhibitory activity for these six food dyes. The six food dyes tested do not interact with P-gp in vitro and, therefore, are unlikely cause clinical drug-food dye interactions. Further investigation is necessary to determine whether these food dyes could interact with other drug transporters.
Identifiants
pubmed: 33011351
pii: S0278-6915(20)30675-X
doi: 10.1016/j.fct.2020.111785
pmc: PMC7736516
mid: NIHMS1638731
pii:
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
Food Coloring Agents
0
Verapamil
CJ0O37KU29
Adenosine Triphosphatases
EC 3.6.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111785Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103546
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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