SARS-CoV-2 outbreak investigation in a German meat processing plant.
SARS-CoV-2 super spreading event
aerosol transmission
meat processing plant outbreak
viral genome sequencing
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
07 12 2020
07 12 2020
Historique:
received:
15
08
2020
revised:
23
09
2020
accepted:
25
09
2020
pubmed:
5
10
2020
medline:
17
12
2020
entrez:
4
10
2020
Statut:
ppublish
Résumé
We describe a multifactorial investigation of a SARS-CoV-2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were analyzed. Our results suggest that a single index case transmitted SARS-CoV-2 to co-workers over distances of more than 8 m, within a confined work area in which air is constantly recirculated and cooled. Viral genome sequencing shows that all cases share a set of mutations representing a novel sub-branch in the SARS-CoV-2 C20 clade. We identified the same set of mutations in samples collected in the time period between this initial infection cluster and a subsequent outbreak within the same factory, with the largest number of confirmed SARS-CoV-2 cases in a German meat processing facility reported so far. Our results indicate climate conditions, fresh air exchange rates, and airflow as factors that can promote efficient spread of SARS-CoV-2 via long distances and provide insights into possible requirements for pandemic mitigation strategies in industrial workplace settings.
Identifiants
pubmed: 33012091
doi: 10.15252/emmm.202013296
pmc: PMC7646008
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13296Subventions
Organisme : SMART BIOTECS Alliance
Pays : International
Organisme : Helmholtz Association ()
ID : W2/W3-090
Pays : International
Organisme : Federal Ministry of Health (Germany)
ID : HPI-COVID-19
Pays : International
Informations de copyright
© 2020 The Authors Published under the terms of the CC BY 4.0 license.
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