Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues.
Alleles
Amino Acid Sequence
/ genetics
Animals
Antigens
/ immunology
Conserved Sequence
/ genetics
Histocompatibility Antigens Class I
/ genetics
Humans
Macaca fascicularis
Mice
Peptides
/ immunology
Protein Binding
/ genetics
Recombinant Proteins
/ genetics
Sequence Homology, Amino Acid
Species Specificity
T-Lymphocytes
/ immunology
HLA-E Antigens
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 11 2020
15 11 2020
Historique:
received:
13
07
2020
accepted:
07
09
2020
pubmed:
7
10
2020
medline:
15
4
2021
entrez:
6
10
2020
Statut:
ppublish
Résumé
Ag presentation via the nonclassical MHC class Ib molecule HLA-E, with nearly complete identity between the two alleles expressed in humans, HLA-E*01:01 and HLA-E*01:03, can lead to the activation of unconventional T cells in humans. Despite this virtual genetic monomorphism, differences in peptide repertoires binding to the two allelic variants have been reported. To further dissect and compare peptide binding to HLA-E*01:01 and HLA-E*01:03, we used an UV-mediated peptide exchange binding assay and an HPLC-based competition binding assay. In addition, we investigated binding of these same peptides to Mamu-E, the nonhuman primate homologue of human HLA-E, and to the HLA-E-like molecule Qa-1
Identifiants
pubmed: 33020145
pii: jimmunol.2000810
doi: 10.4049/jimmunol.2000810
pmc: PMC7653511
mid: NIHMS1628612
doi:
Substances chimiques
Antigens
0
Histocompatibility Antigens Class I
0
Peptides
0
Recombinant Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2861-2872Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141315
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI127133
Pays : United States
Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
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