Fetal whole heart blood flow imaging using 4D cine MRI.
Blood Flow Velocity
Blood Vessels
/ diagnostic imaging
Female
Fetal Heart
/ diagnostic imaging
Four-Dimensional Computed Tomography
/ methods
Gestational Age
Heart Defects, Congenital
/ diagnostic imaging
Humans
Magnetic Resonance Imaging, Cine
/ methods
Phantoms, Imaging
Pregnancy
Prenatal Diagnosis
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 10 2020
05 10 2020
Historique:
received:
13
09
2019
accepted:
10
09
2020
entrez:
6
10
2020
pubmed:
7
10
2020
medline:
23
10
2020
Statut:
epublish
Résumé
Prenatal detection of congenital heart disease facilitates the opportunity for potentially life-saving care immediately after the baby is born. Echocardiography is routinely used for screening of morphological malformations, but functional measurements of blood flow are scarcely used in fetal echocardiography due to technical assumptions and issues of reliability. Magnetic resonance imaging (MRI) is readily used for quantification of abnormal blood flow in adult hearts, however, existing in utero approaches are compromised by spontaneous fetal motion. Here, we present and validate a novel method of MRI velocity-encoding combined with a motion-robust reconstruction framework for four-dimensional visualization and quantification of blood flow in the human fetal heart and major vessels. We demonstrate simultaneous 4D visualization of the anatomy and circulation, which we use to quantify flow rates through various major vessels. The framework introduced here could enable new clinical opportunities for assessment of the fetal cardiovascular system in both health and disease.
Identifiants
pubmed: 33020487
doi: 10.1038/s41467-020-18790-1
pii: 10.1038/s41467-020-18790-1
pmc: PMC7536221
mid: EMS96572
doi:
Banques de données
figshare
['10.6084/m9.figshare.c.4689437']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4992Subventions
Organisme : Wellcome Trust
ID : 102431
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203148
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K0006355/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203148/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K006355/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
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