Cardiac amyloidosis
amyloid-binding tracers
light-chain
molecular imaging
positron emission tomography
transthyretin
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
05
07
2020
accepted:
12
08
2020
pubmed:
8
10
2020
medline:
13
4
2022
entrez:
7
10
2020
Statut:
ppublish
Résumé
Bone-tracer scintigraphy has an established role in diagnosis of cardiac amyloidosis (CA) as it detects transthyretin amyloidosis (ATTR). Positron emission tomography (PET) with amyloid tracers has shown high sensitivity for detection of both ATTR and light-chain (AL) CA. We aimed to investigate the accuracy of We enrolled patients with CA or non-amyloid heart failure (NA-HF), who underwent cardiac We included 17 patients (12 with CA, 5 with NA-HF). PET/MRI was conducted in 13 patients, while PET/CT was conducted in 4. LGE was detected in 8 of 9 CA patients. Global relaxation time and ECV were higher in CA (1448 vs. 1326, P = 0.02 and 58.9 vs. 33.7%, P = 0.006, respectively). Positive PET studies were demonstrated in 2 of 12 patients with CA (AL and ATTR). Maximal and mean SUV did not differ between groups (2.21 vs. 1.69, P = 0.18 and 1.73 vs. 1.30, P = 0.13). Although protein-independent binding is supported by our results, the diagnostic yield of PET was low. We demonstrate here for the first time the low sensitivity of PET for CA.
Identifiants
pubmed: 33025472
doi: 10.1007/s12350-020-02363-2
pii: 10.1007/s12350-020-02363-2
pmc: PMC8993783
doi:
Substances chimiques
Amyloid
0
Aniline Compounds
0
Benzothiazoles
0
Contrast Media
0
flutemetamol
0F3M7032P5
Gadolinium
AU0V1LM3JT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
779-789Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020. The Author(s).
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