Effects of PCB126 on Adipose-to-Muscle Communication in an
3T3-L1 Cells
Adipocytes
Adiponectin
Adipose Tissue
/ physiology
Animals
Communication
Energy Metabolism
Hazardous Substances
/ toxicity
Insulin
Insulin Resistance
Mice
Mitochondria
Muscle Fibers, Skeletal
Muscles
/ physiology
Phosphorylation
Polychlorinated Biphenyls
/ toxicity
Signal Transduction
/ drug effects
Toxicity Tests
/ methods
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
entrez:
7
10
2020
pubmed:
8
10
2020
medline:
13
1
2021
Statut:
ppublish
Résumé
Exposure to coplanar polychlorinated biphenyls (PCBs) is linked to the development of insulin resistance. Previous studies suggested PCB126 alters muscle mitochondrial function through an indirect mechanism. Given that PCBs are stored in fat, we hypothesized that PCB126 alters adipokine secretion, which in turn affects muscle metabolism. We determined 3T3-L1 adipocytes were exposed to PCB126 ( IR 3T3-L1 adipocytes treated with PCB126 had significantly higher adipokine (adiponectin, IL-6, MCP-1, Taken together, these data suggest that increased adipokine secretion from IR adipocytes exposed to PCB126 might explain impaired glucose uptake in myotubes. https://doi.org/10.1289/EHP7058.
Sections du résumé
BACKGROUND
Exposure to coplanar polychlorinated biphenyls (PCBs) is linked to the development of insulin resistance. Previous studies suggested PCB126 alters muscle mitochondrial function through an indirect mechanism. Given that PCBs are stored in fat, we hypothesized that PCB126 alters adipokine secretion, which in turn affects muscle metabolism.
OBJECTIVES
We determined
METHODS
3T3-L1 adipocytes were exposed to PCB126 (
RESULTS
IR 3T3-L1 adipocytes treated with PCB126 had significantly higher adipokine (adiponectin, IL-6, MCP-1,
DISCUSSION
Taken together, these data suggest that increased adipokine secretion from IR adipocytes exposed to PCB126 might explain impaired glucose uptake in myotubes. https://doi.org/10.1289/EHP7058.
Identifiants
pubmed: 33026256
doi: 10.1289/EHP7058
pmc: PMC7539676
doi:
Substances chimiques
Adiponectin
0
Hazardous Substances
0
Insulin
0
Polychlorinated Biphenyls
DFC2HB4I0K
3,4,5,3',4'-pentachlorobiphenyl
TSH69IA9XF
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107002Références
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