Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.

Adolescent Central Nervous System / microbiology Child Child, Preschool Genetic Variation / genetics Genome-Wide Association Study Humans Infant Meningitis, Pneumococcal / microbiology Phylogeny Polymorphism, Single Nucleotide Sequence Analysis, DNA Streptococcus pneumoniae / genetics Viral Tropism / genetics

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
08 10 2020
Historique:
received: 29 06 2020
accepted: 11 09 2020
entrez: 9 10 2020
pubmed: 10 10 2020
medline: 22 6 2021
Statut: epublish

Résumé

Hyper-virulent Streptococcus pneumoniae serotype 1 strains are endemic in Sub-Saharan Africa and frequently cause lethal meningitis outbreaks. It remains unknown whether genetic variation in serotype 1 strains modulates tropism into cerebrospinal fluid to cause central nervous system (CNS) infections, particularly meningitis. Here, we address this question through a large-scale linear mixed model genome-wide association study of 909 African pneumococcal serotype 1 isolates collected from CNS and non-CNS human samples. By controlling for host age, geography, and strain population structure, we identify genome-wide statistically significant genotype-phenotype associations in surface-exposed choline-binding (P = 5.00 × 10

Identifiants

DOI: 10.1038/s42003-020-01290-9 PMID: 33033372 PMC: PMC7545184
pubmed: 33033372
doi: 10.1038/s42003-020-01290-9
pii: 10.1038/s42003-020-01290-9
pmc: PMC7545184
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

559

Subventions

Organisme : Medical Research Council
ID : MR/P011284/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N023129/1
Pays : United Kingdom
Organisme : Bill & Melinda Gates Foundation
ID : OPP1023440
Pays : United States
Organisme : Medical Research Council
ID : MR/R003076/1
Pays : United Kingdom
Organisme : Bill & Melinda Gates Foundation
ID : OPP1034556
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom

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Auteurs

Chrispin Chaguza (C)

Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. cc19@sanger.ac.uk.
Darwin College, University of Cambridge, Silver Street, Cambridge, UK. cc19@sanger.ac.uk.
ORCID: 0000-0002-2108-1757

Marie Yang (M)

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

Jennifer E Cornick (JE)

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.

Mignon du Plessis (M)

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa.
School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
ORCID: 0000-0001-9186-0679

Rebecca A Gladstone (RA)

Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.

Brenda A Kwambana-Adams (BA)

NIHR Global Health Research Unit on Mucosal Pathogens, Division of Infection and Immunity, University College London, London, UK.
Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Stephanie W Lo (SW)

Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.

Chinelo Ebruke (C)

Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Gerry Tonkin-Hill (G)

Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
ORCID: 0000-0003-4397-2224

Chikondi Peno (C)

Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.

Madikay Senghore (M)

Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

Stephen K Obaro (SK)

Division of Pediatric Infectious Disease, University of Nebraska Medical Center Omaha, Omaha, NE, USA.
International Foundation against Infectious Diseases in Nigeria, Abuja, Nigeria.

Sani Ousmane (S)

Centre de Recherche Médicale et Sanitaire, Niamey, Niger.

Gerd Pluschke (G)

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Jean-Marc Collard (JM)

Centre de Recherche Médicale et Sanitaire, Niamey, Niger.

Betuel Sigaùque (B)

Centro de Investigação em Saúde da Manhiça, Maputo, Mozambique.

Neil French (N)

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

Keith P Klugman (KP)

Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Robert S Heyderman (RS)

Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
NIHR Global Health Research Unit on Mucosal Pathogens, Division of Infection and Immunity, University College London, London, UK.

Lesley McGee (L)

Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
ORCID: 0000-0001-8214-921X

Martin Antonio (M)

Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Warwick Medical School, University of Warwick, Coventry, UK.

Robert F Breiman (RF)

Emory Global Health Institute, Emory University, Atlanta, GA, USA.

Anne von Gottberg (A)

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa.
School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Dean B Everett (DB)

Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.

Aras Kadioglu (A)

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

Stephen D Bentley (SD)

Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. sdb@sanger.ac.uk.
Department of Pathology, University of Cambridge, Cambridge, UK. sdb@sanger.ac.uk.
ORCID: 0000-0001-8094-3751

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Bacterial genome-wide association study of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Bacterial genome-wide association study of...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Bacterial genome-wide association study of...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Bacterial genome-wide association study of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Bacterial genome-wide association study of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Bacterial genome-wide association study of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bacterial genome-wide association study of...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Bacterial genome-wide association study of...
questionsmedicales.fr › Maladies du système nerveux › Méningite › Méningite bactérienne › Méningite à pneumocoques › Bacterial genome-wide association study of...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Bacterial genome-wide association study of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Bacterial genome-wide association study of...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Bacterial genome-wide association study of...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae › Bacterial genome-wide association study of...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Tropisme viral › Bacterial genome-wide association study of...