Capsaicin up-regulates pro-apoptotic activity of thiazolidinediones in glioblastoma cell line.
Apoptosis
/ drug effects
Brain Neoplasms
/ drug therapy
Capsaicin
/ administration & dosage
Cell Line, Tumor
Dose-Response Relationship, Drug
Drug Synergism
Glioblastoma
/ drug therapy
Humans
Ligands
PPAR gamma
/ metabolism
Pioglitazone
/ administration & dosage
Rosiglitazone
/ administration & dosage
TRPV Cation Channels
/ metabolism
Up-Regulation
/ drug effects
Apoptosis
Capsaicin
Glioblastoma
Pioglitazone
Rosiglitazone
Troglitazone
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
02
07
2020
revised:
02
09
2020
accepted:
07
09
2020
pubmed:
11
10
2020
medline:
20
2
2021
entrez:
10
10
2020
Statut:
ppublish
Résumé
Capsaicin (N-vanillyl-8-methyl-alpha-nonenamide), a spicy, neurotoxic component of hot pepper is a ligand of vanilloid type-I (TRPV1) receptor of anti-cancer potential. However, molecular mechanism of its action is not fully understood. We found that capsaicin stimulated intrinsic and extrinsic pathway of apoptosis in human glioblastoma LN-18 cell line and this phenomenon was not dependent on TRPV1. Activation of peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-dependent transcription factor, also induced apoptosis in glioblastoma cells. Although PPARγ ligands (thiazolidinediones - rosiglitazone, pioglitazone) promoted apoptosis in LN-18 cells, capsaicin augmented this effect. We found that capsaicin in a dose dependent manner induced expression of PPARγ in glioblastoma LN-18 cells. These findings suggest that capsaicin-dependent up-regulation of PPARγ represent the mechanism for augmentation of cell death by thiazolidinediones.
Identifiants
pubmed: 33038582
pii: S0753-3322(20)30934-3
doi: 10.1016/j.biopha.2020.110741
pii:
doi:
Substances chimiques
Ligands
0
PPAR gamma
0
TRPV Cation Channels
0
TRPV1 protein, human
0
Rosiglitazone
05V02F2KDG
Capsaicin
S07O44R1ZM
Pioglitazone
X4OV71U42S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110741Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.