Immuno-suppressive hydrogels enhance allogeneic MSC survival after transplantation in the injured brain.

Brain CD8-Positive T-Lymphocytes Hematopoietic Stem Cell Transplantation Hydrogels Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells
Brain injury Hydrogel Immune response Stem cell transplantation

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
01 2021
Historique:
received: 19 03 2020
revised: 15 09 2020
accepted: 20 09 2020
pubmed: 11 10 2020
medline: 25 5 2021
entrez: 10 10 2020
Statut: ppublish

Résumé

Traumatic brain injury (TBI) triggers multiple biochemical and cellular processes that exacerbate brain tissue damage through a secondary injury. Therapies that prevent or limit the evolution of secondary injury could significantly reduce the neurological deficits associated with TBI. Mesenchymal stem cell (MSC) transplantation after TBI can ameliorate neurological deficits by modulating inflammation and enhancing the expression of neurotrophic factors. However, transplanted MSCs can be actively rejected by host immune responses, such as those mediated by cytotoxic CD8

Identifiants

DOI: 10.1016/j.biomaterials.2020.120419 PMID: 33038594
pubmed: 33038594
pii: S0142-9612(20)30665-7
doi: 10.1016/j.biomaterials.2020.120419
pii:
doi:

Substances chimiques

Hydrogels 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

120419

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS079739
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Melissa Alvarado-Velez (M)

Dept. of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Syed Faaiz Enam (SF)

Dept. of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.

Nalini Mehta (N)

Dept. of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.

Johnathan G Lyon (JG)

Dept. of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.

Michelle C LaPlaca (MC)

Dept. of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Ravi V Bellamkonda (RV)

Dept. of Biomedical Engineering, Duke University, Durham, NC, 27708, USA. Electronic address: ravi@duke.edu.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Immuno-suppressive hydrogels enhance...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Immuno-suppressive hydrogels enhance...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Immuno-suppressive hydrogels enhance...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Immuno-suppressive hydrogels enhance...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches mésenchymateuses › Immuno-suppressive hydrogels enhance...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Immuno-suppressive hydrogels enhance...