Gender-related differences in treatment and outcome of extracorporeal cardiopulmonary resuscitation-patients.
Adult
Aged
Cardiopulmonary Resuscitation
/ methods
Creatinine
/ blood
Extracorporeal Membrane Oxygenation
/ statistics & numerical data
Female
Heart Arrest
/ complications
Humans
Liver Function Tests
/ statistics & numerical data
Male
Middle Aged
Renal Dialysis
/ statistics & numerical data
Renal Insufficiency
/ blood
Retrospective Studies
Risk Assessment
/ statistics & numerical data
Risk Factors
Sex Factors
Survival Rate
Time Factors
Treatment Outcome
cardiogenic shock
extracorporeal cardiopulmonary resuscitation
extracorporeal membrane oxygenation
gender
mechanical circulatory devices
Journal
Artificial organs
ISSN: 1525-1594
Titre abrégé: Artif Organs
Pays: United States
ID NLM: 7802778
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
01
10
2020
received:
08
09
2020
accepted:
08
10
2020
pubmed:
15
10
2020
medline:
6
11
2021
entrez:
14
10
2020
Statut:
ppublish
Résumé
Extracorporeal cardiopulmonary resuscitation (eCPR) is a rapidly growing treatment strategy due to significant improvement in selected patients' survival rates. Gender-related differences might impact the outcome of therapeutic measures. Therefore, we sought to investigate patients with eCPR at our interdisciplinary extracorporeal membrane oxygenation center regarding sex-related differences with the view to potentially adjusting current selection criteria. From January 2016 to December 2019, 71 patients underwent eCPR at our institution. Data before eCPR and early outcome parameters were analyzed comparing male and female patients. The cohort analyzed consisted of 60 male (84%) and 11 female (15%) patients. Comparing both groups, male patients significantly more frequently suffered out-of-hospital cardiac arrest (68% male vs. 36% female, P = .04), whereas female patients were associated with more in-hospital cardiac arrest (32% male vs. 64% female, P = .04). Creatinine levels differed significantly (1.5 (1.1;2.1) mg/dL in male vs. 1.0 (0.7;1.5) mg/dL in female patients, P = .03). Also, several hepatic parameters showed a significant difference between the groups: aspartate aminotransferase 423 (249;804) U/L in male vs. 115 (61;408) U/L in female patients, P = .01; alanine aminotransferase 174 (102;446) U/L in male vs. 86 (36;118) U/L in female patients, P = .01). Renal failure requiring hemodialysis occurred more frequently in men than in women (P < .01). There is a significant effect of male sex regarding renal failure with subsequent continuous venovenous hemodialysis (CVVH) (R
Substances chimiques
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
488-494Informations de copyright
© 2020 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation and Wiley Periodicals LLC.
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