Anti-LGI1 Encephalitis Developing Immunoglobulin Responsive Orthostatic Hypotension after Remission.
autonomic dysfunction
leucine-rich glioma-inactivated 1 (LGI1)
limbic encephalitis
orthostatic hypotension (OH)
tilt test
voltage-gated potassium channel (VGKC)
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Sep 2021
15 Sep 2021
Historique:
pubmed:
16
10
2020
medline:
18
9
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
Anti-leucine-rich glioma-inactivated 1 (LGI1) antibody is associated with limbic encephalitis. We herein report a patient with anti-LGI1 encephalitis who developed severe orthostatic hypotension (OH) responsive to immunoglobulin therapy five years after developing symptoms of encephalitis. A 71-year-old man presented with amnesia caused by limbic encephalitis. The symptoms of encephalitis improved partially without any immunotherapy. Five years later, he developed severe OH, and anti-LGI1 antibody was positive. The catecholamine dynamics indicated that the central autonomic nervous system was the lesion of his OH. Intravenous immunoglobulin therapy improved the OH. This case suggests that anti-LGI1 antibody can be associated with severe OH.
Identifiants
pubmed: 33055478
doi: 10.2169/internalmedicine.5359-20
pmc: PMC8502651
doi:
Substances chimiques
Autoantibodies
0
Intracellular Signaling Peptides and Proteins
0
Potassium Channels, Voltage-Gated
0
Leucine
GMW67QNF9C
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3021-3024Références
Curr Hypertens Rep. 2018 Feb 26;20(2):11
pubmed: 29480411
Neurocrit Care. 2018 Oct;29(2):264-272
pubmed: 29651625
Autoimmun Rev. 2016 Oct;15(10):970-4
pubmed: 27485013
J Neurophysiol. 2015 Jul;114(1):159-69
pubmed: 25904713
Eur J Paediatr Neurol. 2018 May;22(3):548-551
pubmed: 29370977
PLoS One. 2015 Mar 19;10(3):e0118312
pubmed: 25790156
Ann Indian Acad Neurol. 2019 Jan-Mar;22(1):121-122
pubmed: 30692776
J Neurol Sci. 2014 Aug 15;343(1-2):198-202
pubmed: 24928080
J Neurosci. 2013 Nov 13;33(46):18161-74
pubmed: 24227725
J Neurosci. 2012 Jan 4;32(1):372-80
pubmed: 22219297
Am J Med. 1983 Feb;74(2):265-71
pubmed: 6824005
Ann Neurol. 2012 Aug;72(2):241-55
pubmed: 22473710
Lancet Neurol. 2008 Dec;7(12):1091-8
pubmed: 18851928
Nephrol Ther. 2017 Apr;13 Suppl 1:S55-S67
pubmed: 28577744