Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

Adult Africa / ethnology Aged Aged, 80 and over Black People / genetics Cell Self Renewal / genetics Clonal Hematopoiesis / genetics DNA-Binding Proteins / genetics Dioxygenases Female Genetic Predisposition to Disease Genome, Human / genetics Germ-Line Mutation / genetics Hematopoietic Stem Cells / cytology Humans Intracellular Signaling Peptides and Proteins / genetics Male Middle Aged National Heart, Lung, and Blood Institute (U.S.) Phenotype Precision Medicine Proto-Oncogene Proteins / genetics Tripartite Motif Proteins / genetics United States Whole Genome Sequencing alpha Karyopherins / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
10 2020
Historique:
received: 25 09 2019
accepted: 03 07 2020
pubmed: 16 10 2020
medline: 3 2 2021
entrez: 15 10 2020
Statut: ppublish

Résumé

Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown

Identifiants

DOI: 10.1038/s41586-020-2819-2 PMID: 33057201 PMC: PMC7944936
pubmed: 33057201
doi: 10.1038/s41586-020-2819-2
pii: 10.1038/s41586-020-2819-2
pmc: PMC7944936
mid: NIHMS1609346
doi:

Substances chimiques

DNA-Binding Proteins 0
Intracellular Signaling Peptides and Proteins 0
KPNA4 protein, human 0
Proto-Oncogene Proteins 0
TRIM59 protein, human 0
Tripartite Motif Proteins 0
alpha Karyopherins 0
Dioxygenases EC 1.13.11.-
TET2 protein, human EC 1.13.11.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

763-768

Subventions

Organisme : NHLBI NIH HHS
ID : K01 HL136700
Pays : United States
Organisme : NHLBI NIH HHS
ID : P50 HL118006
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138737
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL141601
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132476
Pays : United States
Organisme : NHLBI NIH HHS
ID : DP2 HL157540
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL137162
Pays : United States
Organisme : NHLBI NIH HHS
ID : R03 HL154284
Pays : United States
Organisme : NHLBI NIH HHS
ID : UG3 HL151865
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117626
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL055673
Pays : United States
Organisme : NHLBI NIH HHS
ID : F30 HL149180
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113323
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139731
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA253125
Pays : United States
Organisme : NIH HHS
ID : DP5 OD029586
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133040
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL091357
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG008895
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG009974
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148565
Pays : United States
Organisme : NHLBI NIH HHS
ID : UH3 HL151865
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL129982
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135818
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132825
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115428
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148050
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149836
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 18SFRN34250007
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL135405
Pays : United States

Investigateurs

Namiko Abe (N)
Christine Albert (C)
Laura Almasy (L)
Alvaro Alonso (A)
Seth Ament (S)
Peter Anderson (P)
Pramod Anugu (P)
Deborah Applebaum-Bowden (D)
Dan Arking (D)
Allison Ashley-Koch (A)
Stella Aslibekyan (S)
Tim Assimes (T)
Dimitrios Avramopoulos (D)
John Barnard (J)
R Graham Barr (RG)
Emily Barron-Casella (E)
Lucas Barwick (L)
Terri Beaty (T)
Gerald Beck (G)
Diane Becker (D)
Rebecca Beer (R)
Amber Beitelshees (A)
Emelia Benjamin (E)
Panagiotis Benos (P)
Marcos Bezerra (M)
Larry Bielak (L)
Russell Bowler (R)
Jennifer Brody (J)
Ulrich Broeckel (U)
Karen Bunting (K)
Carlos Bustamante (C)
Jonathan Cardwell (J)
Vincent Carey (V)
Cara Carty (C)
Richard Casaburi (R)
James Casella (J)
Peter Castaldi (P)
Mark Chaffin (M)
Christy Chang (C)
Yi-Cheng Chang (YC)
Daniel Chasman (D)
Sameer Chavan (S)
Bo-Juen Chen (BJ)
Wei-Min Chen (WM)
Seung Hoan Choi (SH)
Lee-Ming Chuang (LM)
Mina Chung (M)
Ren-Hua Chung (RH)
Clary Clish (C)
Suzy Comhair (S)
Elaine Cornell (E)
Carolyn Crandall (C)
James Crapo (J)
Jeffrey Curtis (J)
Coleen Damcott (C)
Sayantan Das (S)
Sean David (S)
Colleen Davis (C)
Michael DeBaun (M)
Ranjan Deka (R)
Dawn DeMeo (D)
Scott Devine (S)
Qing Duan (Q)
Ravi Duggirala (R)
Susan Dutcher (S)
Charles Eaton (C)
Lynette Ekunwe (L)
Adel El Boueiz (AE)
Leslie Emery (L)
Serpil Erzurum (S)
Charles Farber (C)
Matthew Flickinger (M)
Nora Franceschini (N)
Chris Frazar (C)
Mao Fu (M)
Stephanie M Fullerton (SM)
Lucinda Fulton (L)
Stacey Gabriel (S)
Weiniu Gan (W)
Shanshan Gao (S)
Yan Gao (Y)
Margery Gass (M)
Bruce Gelb (B)
Xiaoqi Priscilla Geng (X)
Mark Geraci (M)
Soren Germer (S)
Robert Gerszten (R)
Auyon Ghosh (A)
Richard Gibbs (R)
Chris Gignoux (C)
Mark Gladwin (M)
David Glahn (D)
Da-Wei Gong (DW)
Harald Goring (H)
Sharon Graw (S)
Daniel Grine (D)
C Charles Gu (CC)
Yue Guan (Y)
Namrata Gupta (N)
Jeff Haessler (J)
Michael Hall (M)
Daniel Harris (D)
Nicola L Hawley (NL)
Ben Heavner (B)
Ryan Hernandez (R)
David Herrington (D)
Craig Hersh (C)
Bertha Hidalgo (B)
Brian Hobbs (B)
John Hokanson (J)
Elliott Hong (E)
Karin Hoth (K)
Chao Agnes Hsiung (C)
Yi-Jen Hung (YJ)
Haley Huston (H)
Chii Min Hwu (CM)
Rebecca Jackson (R)
Deepti Jain (D)
Cashell Jaquish (C)
Min A Jhun (MA)
Craig Johnson (C)
Rich Johnston (R)
Kimberly Jones (K)
Hyun Min Kang (HM)
Shannon Kelly (S)
Michael Kessler (M)
Alyna Khan (A)
Wonji Kim (W)
Greg Kinney (G)
Holly Kramer (H)
Christoph Lange (C)
Meryl LeBoff (M)
Seunggeun Shawn Lee (SS)
Wen-Jane Lee (WJ)
Jonathon LeFaive (J)
David Levine (D)
Joshua Lewis (J)
Xiaohui Li (X)
Yun Li (Y)
Henry Lin (H)
Honghuang Lin (H)
Keng Han Lin (KH)
Xihong Lin (X)
Simin Liu (S)
Yu Liu (Y)
Kathryn Lunetta (K)
James Luo (J)
Michael Mahaney (M)
Barry Make (B)
Ani Manichaikul (A)
Lauren Margolin (L)
Lisa Martin (L)
Susan Mathai (S)
Susanne May (S)
Patrick McArdle (P)
Merry-Lynn McDonald (ML)
Sean McFarland (S)
Daniel McGoldrick (D)
Caitlin McHugh (C)
Hao Mei (H)
Luisa Mestroni (L)
Julie Mikulla (J)
Nancy Min (N)
Mollie Minear (M)
Ryan L Minster (RL)
Matt Moll (M)
Courtney Montgomery (C)
Solomon Musani (S)
Stanford Mwasongwe (S)
Josyf C Mychaleckyj (JC)
Girish Nadkarni (G)
Rakhi Naik (R)
Take Naseri (T)
Sergei Nekhai (S)
Sarah C Nelson (SC)
Bonnie Neltner (B)
Deborah Nickerson (D)
Jeff O'Connell (J)
Tim O'Connor (T)
Heather Ochs-Balcom (H)
David Paik (D)
James Pankow (J)
George Papanicolaou (G)
Afshin Parsa (A)
Marco Perez (M)
James Perry (J)
Ulrike Peters (U)
Patricia Peyser (P)
Lawrence S Phillips (LS)
Toni Pollin (T)
Wendy Post (W)
Julia Powers Becker (JP)
Meher Preethi Boorgula (MP)
Michael Preuss (M)
Pankaj Qasba (P)
Dandi Qiao (D)
Zhaohui Qin (Z)
Laura Rasmussen-Torvik (L)
Aakrosh Ratan (A)
Robert Reed (R)
Elizabeth Regan (E)
Muagututi'a Sefuiva Reupena (M)
Ken Rice (K)
Carolina Roselli (C)
Ingo Ruczinski (I)
Pamela Russell (P)
Sarah Ruuska (S)
Kathleen Ryan (K)
Danish Saleheen (D)
Shabnam Salimi (S)
Steven Salzberg (S)
Kevin Sandow (K)
Christopher Scheller (C)
Ellen Schmidt (E)
Karen Schwander (K)
Frank Sciurba (F)
Christine Seidman (C)
Jonathan Seidman (J)
Vivien Sheehan (V)
Stephanie L Sherman (SL)
Amol Shetty (A)
Aniket Shetty (A)
Brian Silver (B)
Josh Smith (J)
Tanja Smith (T)
Sylvia Smoller (S)
Beverly Snively (B)
Michael Snyder (M)
Tamar Sofer (T)
Nona Sotoodehnia (N)
Adrienne M Stilp (AM)
Garrett Storm (G)
Elizabeth Streeten (E)
Jessica Lasky Su (JL)
Yun Ju Sung (YJ)
Jody Sylvia (J)
Adam Szpiro (A)
Carole Sztalryd (C)
Daniel Taliun (D)
Hua Tang (H)
Matthew Taylor (M)
Simeon Taylor (S)
Marilyn Telen (M)
Timothy A Thornton (TA)
Machiko Threlkeld (M)
Lesley Tinker (L)
David Tirschwell (D)
Sarah Tishkoff (S)
Hemant Tiwari (H)
Catherine Tong (C)
Michael Tsai (M)
Dhananjay Vaidya (D)
David Van Den Berg (DVD)
Peter VandeHaar (P)
Scott Vrieze (S)
Tarik Walker (T)
Robert Wallace (R)
Avram Walts (A)
Heming Wang (H)
Karol Watson (K)
Bruce Weir (B)
Lu-Chen Weng (LC)
Jennifer Wessel (J)
Cristen Willer (C)
Kayleen Williams (K)
Carla Wilson (C)
Joseph Wu (J)
Huichun Xu (H)
Lisa Yanek (L)
Rongze Yang (R)
Norann Zaghloul (N)
Yingze Zhang (Y)
Snow Xueyan Zhao (SX)
Wei Zhao (W)
Degui Zhi (D)
Xiang Zhou (X)
Xiaofeng Zhu (X)
Michael Zody (M)
Sebastian Zoellner (S)

Commentaires et corrections

Type : ErratumIn

Références

Biostatistics. 2007 Jan;8(1):118-27
pubmed: 16632515
Nat Biotechnol. 2013 Mar;31(3):213-9
pubmed: 23396013
Blood. 2017 Aug 10;130(6):742-752
pubmed: 28483762
Genome Res. 2015 Jun;25(6):918-25
pubmed: 25883319
Nature. 2016 May 02;534(7605):47-54
pubmed: 27135926
Nat Genet. 2018 Sep;50(9):1335-1341
pubmed: 30104761
Nat Genet. 2009 Apr;41(4):450-4
pubmed: 19287385
Nat Commun. 2018 Oct 2;9(1):4038
pubmed: 30279509
Cancer Cell. 2011 Jul 12;20(1):11-24
pubmed: 21723200
Nat Genet. 2016 May;48(5):563-8
pubmed: 27064253
Mol Genet Genomic Med. 2018 May 8;:
pubmed: 29739035
Nat Commun. 2018 Aug 23;9(1):3391
pubmed: 30140000
J Infect Dis. 2015 Nov 15;212(10):1563-73
pubmed: 25969563
Bioinformatics. 2016 May 15;32(10):1493-501
pubmed: 26773131
Blood. 2016 Aug 25;128(8):1121-8
pubmed: 27365426
N Engl J Med. 2014 Dec 25;371(26):2477-87
pubmed: 25426838
Bioinformatics. 2012 Jun 1;28(11):1530-2
pubmed: 22539670
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Am J Hum Genet. 2004 Dec;75(6):1131-5
pubmed: 15492928
Nat Commun. 2016 Aug 22;7:12484
pubmed: 27546487
Cell. 2014 Nov 6;159(4):709-13
pubmed: 25417146
J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):258-65
pubmed: 19880817
Nat Genet. 2013 Apr;45(4):371-84, 384e1-2
pubmed: 23535731
Genet Epidemiol. 2019 Mar;43(2):227-237
pubmed: 30565316
Nat Genet. 2015 Dec;47(12):1402-7
pubmed: 26551669
Genet Epidemiol. 2010 Dec;34(8):816-34
pubmed: 21058334
Cell Stem Cell. 2018 Feb 1;22(2):157-170
pubmed: 29395053
Genome Res. 2013 Jan;23(1):152-8
pubmed: 23028187
Blood. 2006 Jul 15;108(2):638-44
pubmed: 16574953
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Genome Med. 2018 Apr 25;10(1):33
pubmed: 29695279
N Engl J Med. 2017 Jul 13;377(2):111-121
pubmed: 28636844
Nat Genet. 2019 Mar;51(3):568-576
pubmed: 30804563
Sci Rep. 2019 Jun 27;9(1):9354
pubmed: 31249361
Nat Med. 2014 Dec;20(12):1472-8
pubmed: 25326804
Nat Genet. 2009 Apr;41(4):455-9
pubmed: 19287384
Circulation. 2020 Jan 14;141(2):124-131
pubmed: 31707836
J Clin Oncol. 2017 May 10;35(14):1598-1605
pubmed: 28068180
Nat Genet. 2019 Dec;51(12):1664-1669
pubmed: 31784727
Blood. 2013 Jul 18;122(3):376-85
pubmed: 23723449
Nat Genet. 2009 Apr;41(4):446-9
pubmed: 19287382
Nature. 2018 Jul;559(7714):350-355
pubmed: 29995854
N Engl J Med. 2014 Dec 25;371(26):2488-98
pubmed: 25426837
Bioinformatics. 2012 May 1;28(9):1280-1
pubmed: 22451269
Nature. 2021 Feb;590(7845):290-299
pubmed: 33568819
J Biol Chem. 2018 Feb 16;293(7):2452-2465
pubmed: 29279332
Nat Med. 2018 Jul;24(7):1015-1023
pubmed: 29988143
Nat Genet. 2017 Dec;49(12):1664-1670
pubmed: 29019975
Blood. 2015 Jul 2;126(1):9-16
pubmed: 25931582
Genome Res. 2013 May;23(5):843-54
pubmed: 23382536

Auteurs

Alexander G Bick (AG)

Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Joshua S Weinstock (JS)

Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0001-7013-1899

Satish K Nandakumar (SK)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Charles P Fulco (CP)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-6592-1279

Erik L Bao (EL)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-6074-6766

Seyedeh M Zekavat (SM)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Yale School of Medicine, New Haven, CT, USA.

Mindy D Szeto (MD)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
ORCID: 0000-0003-3642-3753

Xiaotian Liao (X)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
ORCID: 0000-0002-9715-270X

Matthew J Leventhal (MJ)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Joseph Nasser (J)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Kyle Chang (K)

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cecelia Laurie (C)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Bala Bharathi Burugula (BB)

Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.

Christopher J Gibson (CJ)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Amy E Lin (AE)

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Margaret A Taub (MA)

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Francois Aguet (F)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Kristin Ardlie (K)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Braxton D Mitchell (BD)

Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.

Kathleen C Barnes (KC)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.

Arden Moscati (A)

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Myriam Fornage (M)

Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.

Susan Redline (S)

Harvard Medical School, Boston, MA, USA.
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Department of Health Services, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Edwin K Silverman (EK)

Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Scott T Weiss (ST)

Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Nicholette D Palmer (ND)

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Ramachandran S Vasan (RS)

Departments of Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA.

Esteban G Burchard (EG)

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, USA.

Sharon L R Kardia (SLR)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Jiang He (J)

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Tulane University Translational Science Institute, New Orleans, LA, USA.

Robert C Kaplan (RC)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.

Nicholas L Smith (NL)

Department of Epidemiology, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Seattle Epidemiologic Information and Research Center, Department of Veterans Affairs, Office of Research and Development, Seattle, WA, USA.

Donna K Arnett (DK)

College of Public Health, University of Kentucky, Lexington, KY, USA.

David A Schwartz (DA)

Department of Medicine, University of Colorado, Aurora, CO, USA.

Adolfo Correa (A)

Departments of Medicine and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.

Mariza de Andrade (M)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

Xiuqing Guo (X)

Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Barbara A Konkle (BA)

Bloodworks Northwest, Seattle, WA, USA.
Department of Medicine, University of Washington, Seattle, WA, USA.

Brian Custer (B)

Vitalant Research Institute, San Francisco, CA, USA.
Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Juan M Peralta (JM)

Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.

Hongsheng Gui (H)

Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.

Deborah A Meyers (DA)

Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.

Stephen T McGarvey (ST)

Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA.

Ida Yii-Der Chen (IY)

Medical Genetics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA.

M Benjamin Shoemaker (MB)

Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Patricia A Peyser (PA)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Jai G Broome (JG)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Stephanie M Gogarten (SM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Fei Fei Wang (FF)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Quenna Wong (Q)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

May E Montasser (ME)

Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Michelle Daya (M)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Eimear E Kenny (EE)

Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Kari E North (KE)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

Lenore J Launer (LJ)

Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA.

Brian E Cade (BE)

Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA.

Joshua C Bis (JC)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.

Michael H Cho (MH)

Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Jessica Lasky-Su (J)

Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Donald W Bowden (DW)

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.

L Adrienne Cupples (LA)

Departments of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Angel C Y Mak (ACY)

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Lewis C Becker (LC)

GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Jennifer A Smith (JA)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.

Tanika N Kelly (TN)

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Tulane University Translational Science Institute, New Orleans, LA, USA.

Stella Aslibekyan (S)

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Susan R Heckbert (SR)

Department of Epidemiology, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Hemant K Tiwari (HK)

Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.

Ivana V Yang (IV)

Department of Medicine, University of Colorado, Aurora, CO, USA.

John A Heit (JA)

Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Steven A Lubitz (SA)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

Jill M Johnsen (JM)

Bloodworks Northwest, Seattle, WA, USA.
Department of Medicine, University of Washington, Seattle, WA, USA.

Joanne E Curran (JE)

Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.

Sally E Wenzel (SE)

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Daniel E Weeks (DE)

Departments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Dabeeru C Rao (DC)

Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.

Dawood Darbar (D)

Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.

Jee-Young Moon (JY)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.

Russell P Tracy (RP)

Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.

Erin J Buth (EJ)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Nicholas Rafaels (N)

Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.

Ruth J F Loos (RJF)

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Peter Durda (P)

Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.

Yongmei Liu (Y)

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Lifang Hou (L)

Department of Preventive Medicine, Northwestern Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Jiwon Lee (J)

Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Priyadarshini Kachroo (P)

Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Barry I Freedman (BI)

Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Daniel Levy (D)

Framingham Heart Study, Framingham, MA, USA.
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Lawrence F Bielak (LF)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

James E Hixson (JE)

Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.

James S Floyd (JS)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Department of Medicine, University of Washington, Seattle, WA, USA.

Eric A Whitsel (EA)

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.

Patrick T Ellinor (PT)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

Marguerite R Irvin (MR)

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Tasha E Fingerlin (TE)

Center for Genes Environment and Health, National Jewish Health, Denver, CO, USA.

Laura M Raffield (LM)

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.

Sebastian M Armasu (SM)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

Marsha M Wheeler (MM)

Department of Genome Science, University of Washington, Seattle, WA, USA.

Ester C Sabino (EC)

Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

John Blangero (J)

Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.

L Keoki Williams (LK)

Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.

Bruce D Levy (BD)

Harvard Medical School, Boston, MA, USA.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Wayne Huey-Herng Sheu (WH)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Dan M Roden (DM)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Eric Boerwinkle (E)

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.

JoAnn E Manson (JE)

Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.

Rasika A Mathias (RA)

GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Pinkal Desai (P)

Department of Medicine, Weill Cornell Medical School, New York, NY, USA.

Kent D Taylor (KD)

Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.

Andrew D Johnson (AD)

Framingham Heart Study, Framingham, MA, USA.
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Paul L Auer (PL)

Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.

Charles Kooperberg (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Cathy C Laurie (CC)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Thomas W Blackwell (TW)

Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Albert V Smith (AV)

Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Hongyu Zhao (H)

Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.
Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.
ORCID: 0000-0003-1195-9607

Ethan Lange (E)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Leslie Lange (L)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Stephen S Rich (SS)

Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.

Jerome I Rotter (JI)

Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.

James G Wilson (JG)

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Paul Scheet (P)

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Jacob O Kitzman (JO)

Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-6145-882X

Eric S Lander (ES)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Department of Biology, MIT, Cambridge, MA, USA.

Jesse M Engreitz (JM)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Society of Fellows, Harvard University, Cambridge, MA, USA.
ORCID: 0000-0002-5754-1719

Benjamin L Ebert (BL)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Howard Hughes Medical Institute, Boston, MA, USA.
ORCID: 0000-0003-0197-5451

Alexander P Reiner (AP)

Department of Epidemiology, University of Washington, Seattle, WA, USA.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Siddhartha Jaiswal (S)

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Gonçalo Abecasis (G)

Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Regeneron Pharmaceuticals, Tarrytown, NY, USA.
ORCID: 0000-0003-1509-1825

Vijay G Sankaran (VG)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.
Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
ORCID: 0000-0003-0044-443X

Sekar Kathiresan (S)

Broad Institute of MIT and Harvard, Cambridge, MA, USA. sekar@broadinstitute.org.
Harvard Medical School, Boston, MA, USA. sekar@broadinstitute.org.
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. sekar@broadinstitute.org.
Verve Therapeutics, Cambridge, MA, USA. sekar@broadinstitute.org.
ORCID: 0000-0002-6724-032X

Pradeep Natarajan (P)

Broad Institute of MIT and Harvard, Cambridge, MA, USA. pradeep@broadinstitute.org.
Harvard Medical School, Boston, MA, USA. pradeep@broadinstitute.org.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. pradeep@broadinstitute.org.
ORCID: 0000-0001-8402-7435

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Régions géographiques › Afrique › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Personnes › Noirs › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Auto-renouvellement cellulaire › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Hématopoïèse clonale › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome humain › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation germinale › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Organisations et économie des soins de santé › Organismes › Gouvernement › Agences gouvernementale américaines › Department of Health and Human Services (USA) › Public Health Service (USA) › National Institutes of Health (USA) › National Heart, Lung, and Blood Institute (USA) › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à motif tripartite › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Inherited causes of clonal haematopoiesis in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Caryophérines › Cariophérines alpha › Inherited causes of clonal haematopoiesis in...