Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD.

Administration, Inhalation Adrenergic beta-2 Receptor Agonists / therapeutic use Aged Bronchodilator Agents / administration & dosage Budesonide / administration & dosage Case-Control Studies Dose-Response Relationship, Drug Female Formoterol Fumarate / administration & dosage Gene Expression Profiling Humans Lung / physiopathology Male Middle Aged Nasal Cavity / metabolism Placebos Pulmonary Disease, Chronic Obstructive / drug therapy

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
15 10 2020
Historique:
received: 23 11 2018
accepted: 27 08 2020
entrez: 16 10 2020
pubmed: 17 10 2020
medline: 9 3 2021
Statut: epublish

Résumé

Hyperinflation contributes to dyspnea intensity in COPD. Little is known about the molecular mechanisms underlying hyperinflation and how inhaled corticosteroids (ICS) affect this important aspect of COPD pathophysiology. To investigate the effect of ICS/long-acting β

Identifiants

DOI: 10.1038/s41598-020-72551-0 PMID: 33060632 PMC: PMC7562702
pubmed: 33060632
doi: 10.1038/s41598-020-72551-0
pii: 10.1038/s41598-020-72551-0
pmc: PMC7562702
doi:

Substances chimiques

Adrenergic beta-2 Receptor Agonists 0
Bronchodilator Agents 0
Placebos 0
Budesonide 51333-22-3
Formoterol Fumarate W34SHF8J2K

Banques de données

ClinicalTrials.gov
['NCT01351792', 'NCT00848406', 'NCT00158847']

Types de publication

Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

17415

Références

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pubmed: 10836347

Auteurs

Alen Faiz (A)

Department of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Pathology & Medical Biology, Section Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Kai Imkamp (K)

Department of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. k.imkamp@umcg.nl.
GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. k.imkamp@umcg.nl.

Erica van der Wiel (E)

Department of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Ilse M Boudewijn (IM)

Department of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Gerard H Koppelman (GH)

GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0001-8567-3252

Corry-Anke Brandsma (CA)

GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0001-8911-3658

Huib A M Kerstjens (HAM)

Department of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0001-7705-7927

Wim Timens (W)

GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0002-4146-6363

Sebastiaan Vroegop (S)

Department of Pulmonary Diseases, Martini Hospital Groningen, Groningen, The Netherlands.

Henk R Pasma (HR)

Department of Pulmonary Diseases, Medical Center Leeuwarden, Leeuwarden, The Netherlands.

Wim G Boersma (WG)

Department of Pulmonary Diseases, Medical Center Alkmaar, Alkmaar, The Netherlands.

Pascal Wielders (P)

Department of Pulmonary Diseases, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
ORCID: 0000-0003-3719-5967

Frank van den Elshout (F)

Department of Pulmonary Diseases, Rijnstate Hospital, Arnhem, The Netherlands.

Khaled Mansour (K)

Department of Pulmonary Diseases, Orbis Concern, Sittard, The Netherlands.

Katrina Steiling (K)

Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Avrum Spira (A)

Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Marc E Lenburg (ME)

Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Irene H Heijink (IH)

GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Pathology & Medical Biology, Section Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Dirkje S Postma (DS)

Department of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Maarten van den Berge (M)

Department of Pulmonology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par inhalation › Identifying a nasal gene expression signature...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Agonistes adrénergiques › Agonistes bêta-adrénergiques › Agonistes des récepteurs béta-2 adrénergiques › Identifying a nasal gene expression signature...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Identifying a nasal gene expression signature...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents de l'appareil respiratoire › Antiasthmatiques › Bronchodilatateurs › Identifying a nasal gene expression signature...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnènes › Prégnènediones › Budésonide › Identifying a nasal gene expression signature...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Identifying a nasal gene expression signature...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Identifying a nasal gene expression signature...
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Éthanolamines › Fumarate de formotérol › Identifying a nasal gene expression signature...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Identifying a nasal gene expression signature...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identifying a nasal gene expression signature...
questionsmedicales.fr › Appareil respiratoire › Poumon › Identifying a nasal gene expression signature...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Identifying a nasal gene expression signature...
questionsmedicales.fr › Appareil respiratoire › Fosse nasale › Identifying a nasal gene expression signature...
questionsmedicales.fr › Thérapeutique › Placebo › Identifying a nasal gene expression signature...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Broncho-pneumopathie chronique obstructive › Identifying a nasal gene expression signature...